Neubert R, Fürst W, Schulze P, Loh H J, Jirka M, Wenzel U
Sektion Pharmazie, Martin-Luther-Universität Halle-Wittenberg.
Pharmazie. 1987 Jun;42(6):393-4.
The influence of the hexylsalicylic acid (2) on the pharmacokinetic of the quinine (1), was studied using rabbits. It could be observed that after i.v. application the mean resistance time (MRT) of 1 was increased by means of ion-pair-formation with 2. But the AUC of 1 was not influenced. After rectal application of the combination 1/2 an acceleration of the 1 absorption could be pointed out. The kinetic parameters of 2 were not increased significantly if 1 was applicated simultaneously.
使用兔子研究了己基水杨酸（2）对奎宁（1）药代动力学的影响。可以观察到，静脉注射后，通过与2形成离子对，1的平均滞留时间（MRT）增加。但1的曲线下面积（AUC）不受影响。直肠应用1/2组合后，可指出1的吸收加速。如果同时应用1，2的动力学参数没有显著增加。
