Neubert R, Ritter A, Stolte E, Albrecht G, Loh H J, Jirka M, Fürst W
Sektion Pharmazie, Martin-Luther-Universität Halle.
Pharmazie. 1988 Dec;43(12):848-50.
Based on in vitro results it was found that the pharmacokinetic parameters of the hydrophilic drug bretylium (2) can be influenced by an ion-pair-formation with the lipophilic hexylsalicyclic acid (1). After simultaneous i.v. application of 1 and 2 on rabbits a significant increase of the AUC of 2 was observed. Under these conditions a marked increase of the AUC and the MRT of 1 was also obtained, since the blood levels of 2 are high enough for such an influence. A combined rectal application of 1 and 2 causes an increase of the AUC of 2.
基于体外实验结果发现，亲水性药物溴苄铵（2）的药代动力学参数会受到与亲脂性己基水杨酸（1）形成离子对的影响。在兔身上同时静脉注射1和2后，观察到2的AUC显著增加。在这些条件下，1的AUC和MRT也显著增加，因为2的血药浓度足以产生这种影响。1和2联合直肠给药会使2的AUC增加。
