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关于骨水泥中具有前景的抗菌剂的综述——从过去到现在的见解。

A review on the promising antibacterial agents in bone cement-From past to current insights.

机构信息

Department of Orthopedics, The Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, Hefei, 230011, Anhui, China.

Department of Orthopedics, Hefei BOE Hospital, Teaching Hospital of Shanghai University Medical College, Hefei, 230013, Anhui, China.

出版信息

J Orthop Surg Res. 2024 Oct 20;19(1):673. doi: 10.1186/s13018-024-05143-7.

DOI:10.1186/s13018-024-05143-7
PMID:39428491
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11492595/
Abstract

Antibacterial bone cements (ABCs), such as antibiotic-loaded bone cements (ALBCs), have been widely utilized in clinical treatments. Currently, bone cements loaded with vancomycin, gentamicin, tobramycin, or clindamycin are approved by the US Food and Drug Administration. However, traditional ALBCs exhibit drawbacks like burst release and bacterial resistance. Therefore, there is a demand for the development of antibacterial bone cements containing novel agents to address these defects. In this review, we provide an overview and prospect of the new antibacterial agents that can be used or have the potential to be applied in bone cement, including metallic antibacterial agents, pH-switchable antibacterial agents, cationic polymers, N-halamines, non-leaching acrylic monomers, antimicrobial peptides and enzymes. Additionally, we have conducted a preliminary assessment of the feasibility of bone cement containing N-halamine, which has demonstrated good antibacterial activities. The conclusion of this review is that the research and utilization of bone cement containing novel antibacterial agents contribute to addressing the limitations of ALBCs. Therefore, it is necessary to continue expanding the research and use of bone cement incorporating novel antibacterial agents. This review offers a novel perspectives for designing ABCs and treating bone infections.

摘要

抗菌骨水泥（ABCs），如载抗生素骨水泥（ALBCs），已广泛应用于临床治疗。目前，载有万古霉素、庆大霉素、妥布霉素或克林霉素的骨水泥已获得美国食品和药物管理局的批准。然而，传统的 ALBCs 存在突释和细菌耐药性等缺点。因此，需要开发含有新型药物的抗菌骨水泥来解决这些缺陷。在这篇综述中，我们提供了可以或有可能应用于骨水泥中的新型抗菌剂的概述和展望，包括金属抗菌剂、pH 切换型抗菌剂、阳离子聚合物、N-卤胺、非浸出性丙烯酸单体、抗菌肽和酶。此外，我们对含有 N-卤胺的骨水泥的可行性进行了初步评估，该骨水泥具有良好的抗菌活性。本综述的结论是，研究和应用新型抗菌骨水泥有助于解决 ALBCs 的局限性。因此，有必要继续扩大新型抗菌骨水泥的研究和应用。本综述为设计 ABCs 和治疗骨感染提供了新的视角。

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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a13/11492595/c1ff1827d265/13018_2024_5143_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a13/11492595/8bf688718b7b/13018_2024_5143_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a13/11492595/42bc4c68ad42/13018_2024_5143_Fig8_HTML.jpg
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