Tsuji Kenji, Kitamura Shinji
Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-2 Shikata-cho, Okayama, Okayama 700-8558, Japan.
Stem Cells Int. 2015;2015:537204. doi: 10.1155/2015/537204. Epub 2015 May 18.
Stem cell therapies against renal injury have been advancing. The many trials for renal regeneration are reported to be effective in many kinds of renal injury models. Regarding the therapeutic mechanism, it is believed that stem cells contribute to make regeneration via not only direct stem cell differentiation in the injured space but also indirect effect via secreted factors from stem cells. Direct differentiation from stem cells to renal composed cells has been reported. They differentiate to renal composed cells and make functions. However, regarding renal regeneration, stem cells are discussed to secrete many kinds of growth factors, cytokines, and chemokines in paracrine or autocrine manner, which protect against renal injury, too. In addition, it is reported that stem cells have the ability to communicate with nearby cells via microvesicle-related RNA and proteins. Taken together from many reports, many secreted factors from stem cells were needed for renal regeneration orchestrally with harmony. In this review, we focused on the effects and insights of stem cells and regenerative factors from stem cells.
针对肾损伤的干细胞疗法一直在不断发展。据报道，许多肾脏再生试验在多种肾损伤模型中均有效。关于治疗机制，人们认为干细胞不仅通过在损伤部位直接分化为肾组成细胞来促进再生，还通过干细胞分泌的因子产生间接作用。已有报道称干细胞可直接分化为肾组成细胞。它们分化为肾组成细胞并发挥功能。然而，关于肾脏再生，人们认为干细胞以旁分泌或自分泌方式分泌多种生长因子、细胞因子和趋化因子，这些也能保护肾脏免受损伤。此外，有报道称干细胞能够通过微泡相关的RNA和蛋白质与附近细胞进行通讯。综合众多报道来看，肾脏再生需要干细胞分泌的多种因子协同发挥作用。在本综述中，我们重点关注了干细胞及其分泌的再生因子的作用和相关见解。
