Wassenaar Trudy M, Gunzer Florian
Molecular Microbiology and Genomics Consultants, Tannenstrasse 7, 55576 Zotzenheim, Germany.
Institute of Medical Microbiology and Hygiene, TU Dresden, Dresden, Germany.
Gut Pathog. 2015 Jun 19;7:15. doi: 10.1186/s13099-015-0062-4. eCollection 2015.
Now that microbial whole genome sequencing is in reach of many researchers, it is common to infer virulent properties of a given bacterial isolate based on the presence of virulence genes. However, this may lead to inaccurate presumptions of virulence. Using the findings of a recent publication (Da Silva Santos et al. Gut Pathog 7:2, 2015) where virulence was inferred from a genome sequence and subsequently confirmed by in vitro analysis, we present an alternative view on the case described in that publication. Our alternative view point, which is further substantiated by whole genome sequencing of probiotic E. coli strains, may contribute to a more balanced vision on the interactions between pathogens and host.
既然许多研究人员都能够进行微生物全基因组测序，那么基于毒力基因的存在来推断特定细菌分离株的毒力特性就很常见。然而，这可能会导致对毒力的不准确推测。利用最近一篇出版物（Da Silva Santos等人，《肠道病原体》7:2，2015年）的研究结果，其中从基因组序列推断出毒力并随后通过体外分析得到证实，我们对该出版物中描述的案例提出了另一种观点。我们的另一种观点，通过益生菌大肠杆菌菌株的全基因组测序得到了进一步证实，可能有助于对病原体与宿主之间的相互作用形成更平衡的认识。
