Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA.
Cell. 2015 Jun 18;161(7):1496-8. doi: 10.1016/j.cell.2015.06.009.
Neuronal activity results in the rapid induction of gene transcription through a series of defined molecular events. Madabhushi et al. describe an unexpected role for the cutting of promoter DNA by topoisomerase IIB to facilitate transcription of activity-induced genes.
神经元活动通过一系列明确的分子事件导致基因转录的快速诱导。Madabhushi 等人描述了拓扑异构酶 IIB 切割启动子 DNA 以促进活性诱导基因转录的意外作用。
