使用商业化的Ph-BPE配体对1-烯烃进行对映选择性氢甲酰化反应。
Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand.
作者信息
Yu Zhiyong, Eno Meredith S, Annis Alexandra H, Morken James P
机构信息
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
出版信息
Org Lett. 2015 Jul 2;17(13):3264-7. doi: 10.1021/acs.orglett.5b01421. Epub 2015 Jun 19.
Abstract
A rhodium complex, in conjunction with commercially available Ph-BPE ligand, catalyzes the branch-selective asymmetric hydroformylation of 1-alkenes and rapidly generates α-chiral aldehydes. A wide range of terminal olefins including 1-dodecene were examined, and all delivered high enantioselectivity (up to 98:2 er) as well as good branch:linear ratios (up to 15:1).
摘要
一种铑配合物与市售的Ph-BPE配体协同作用，催化1-烯烃的支链选择性不对称氢甲酰化反应，并快速生成α-手性醛。研究了包括1-十二碳烯在内的多种末端烯烃，所有这些烯烃都具有高对映选择性（对映体比例高达98:2）以及良好的支链与直链比例（高达15:1）。
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