Department of Microbiology, Immunology, and Molecular Genetics, College of Medicine, University of Kentucky, Lexington, KY 40536, USA.
Ageing Res Rev. 2015 Sep;23(Pt B):139-53. doi: 10.1016/j.arr.2015.03.005. Epub 2015 Jun 17.
This essay begins by proposing that muscle weakness of old age from sarcopenia is due in large part to reduced capillary density in the muscles, as documented in 9 reports of aged persons and animals. Capillary density (CD) is determined by local levels of various angiogenic factors, which also decline in muscles with aging, as reported in 7 studies of old persons and animals. There are also numerous reports of reduced CD in the aged brain and other studies showing reduced CD in the kidney and heart of aged animals. Thus a waning angiogenesis throughout the body may be a natural occurrence in later years and may account significantly for the lesser ailments (physical and cognitive) of elderly people. Old age is regarded here as a deficiency state which may be corrected by therapeutic angiogenesis, much as a hormonal deficiency can be relieved by the appropriate hormone therapy. Such therapy could employ recombinant angiogenic factors which are now commercially available.
这篇文章首先提出，衰老相关性肌肉减少症导致的老年肌肉无力，在很大程度上是由于肌肉中毛细血管密度降低所致，这在 9 份关于老年人和动物的报告中已有记载。毛细血管密度（CD）由局部各种血管生成因子的水平决定，正如 7 项关于老年人和动物的研究报告中所指出的，这些因子在衰老过程中也会下降。还有许多关于老年人大脑 CD 降低的报告，以及其他研究表明老年动物的肾脏和心脏 CD 降低。因此，全身血管生成能力的减弱可能是晚年的自然现象，可能是老年人身体和认知方面不适（较少）的主要原因。在这里，老年被视为一种缺乏状态，可以通过治疗性血管生成来纠正，就像激素缺乏可以通过适当的激素治疗来缓解一样。这种治疗可以使用现在市售的重组血管生成因子。
