雷公藤诺醇A-D：从雷公藤叶片中分离得到的四种新降倍半萜

Wilfordonols A-D: four new norsesquiterpenes from the leaves of Tripterygium wilfordii.

作者信息

Ni Lin, Zhou Xing, Ma Jie, Zhang Xiao-Mei, Li Chuang-Jun, Li Li, Yang Da-Jian, Shao Yang-Yang, Zhou Si-Bai, Zhang Tian-Tai, Zhang Dong-Ming

机构信息

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines , Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.

出版信息

J Asian Nat Prod Res. 2015;17(6):615-24. doi: 10.1080/10286020.2015.1054380. Epub 2015 Jun 22.

DOI:10.1080/10286020.2015.1054380

PMID:26096035

Abstract

Four new norsesquiterpenes wilfordonols A-D (1-4), along with three known compounds, sarmentol B (5), boscialin (6), and (+)-loliolide (7), were isolated from the leaves of Tripterygium wilfordii Hook.f.. The structures of the new compounds were elucidated on the basis of their spectroscopic analysis, and the absolute configuration of the compounds was confirmed by CD and modified Mosher's method. At a concentration of 10 μM, compounds 4, 6, and 7 inhibited signal transducer and activator of transcription 1 translocation by 34.27 ± 1.02%, 48.93 ± 1.76%, and 70.31 ± 2.20%, respectively.

摘要

从雷公藤（Tripterygium wilfordii Hook.f.）的叶子中分离出了四种新的降倍半萜wilfordonols A-D（1-4），以及三种已知化合物，即sarmentol B（5）、boscialin（6）和（+）-loliolide（7）。通过光谱分析阐明了新化合物的结构，并通过圆二色光谱（CD）和改良的莫舍尔方法确定了化合物的绝对构型。在浓度为10 μM时，化合物4、6和7分别抑制信号转导和转录激活因子1的易位34.27±1.02%、48.93±1.76%和70.31±2.20%。