Wang Xiaojing, Wu Yunkou, Soesbe Todd C, Yu Jing, Zhao Piyu, Kiefer Garry E, Sherry A Dean
Department of Chemistry, University of Texas at Dallas, 800 West Campbell Road, Richardson, TX 75080 (USA).
Advanced Imaging Research Center, UT Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390 (USA).
Angew Chem Int Ed Engl. 2015 Jul 20;54(30):8662-4. doi: 10.1002/anie.201502497. Epub 2015 Jun 11.
A terbium-based complex that displays a water exchange CEST resonance well outside the normal magnetization transfer (MT) frequency range of tissues provides a direct readout of pH values by MRI. Deprotonation of the phenolic proton in this complex results in a frequency shift of 56 ppm in a bound water molecule exchange peak between pH 5 and 8. This allows direct imaging of pH without prior knowledge of the agent concentration and with essentially no interference from the tissue MT signal.
一种基于铽的配合物,其水交换CEST共振出现在组织正常磁化转移(MT)频率范围之外,可通过MRI直接读出pH值。该配合物中酚质子的去质子化导致在pH值5至8之间的结合水分子交换峰中出现56 ppm的频率偏移。这使得无需事先了解试剂浓度且基本不受组织MT信号干扰即可直接对pH进行成像。