[Clinico-laboratory parallels in changes in the cerebrospinal fluid and the immune status of patients with early stages of syphilis].

A total of 135 patients with early syphilis were examined, 24 of these with primary seropositive, 31 with secondary new, 70 with secondary relapsing, and 10 with latent early condition. Abnormal shifts were revealed in the cerebrospinal fluid of 51 (37%) patients, in 28 of these Stages I-II shifts, Stages II-III shifts in 10, and Stages III-IV shifts in 13 patients. Clinically the patients with abnormal liquor developed multiple chancres, erosive papules, leukoderma, alopecia, neutrophilia; these patients had suffered from various diseases in the past. Immunologic examinations have detected manifest noncoordination of the immune system: increased counts of the T-lymphocytes and plasmacytes, reduced counts of B-lymphocytes, depressed primary immune response, disordered immunoglobulin ratio.