Peiretti Enrico, Ferrara Daniela C, Caminiti Giulia, Mura Marco, Hughes John
*Department of Surgical Science, Eye Clinic, University of Cagliari, Cagliari, Italy; †New England Eye Center, Tufts Medical Center, Boston, Massachusetts; and ‡Academic Medical Center, Ophthalmology Department,University of Amsterdam, The Netherlands.
Retina. 2015 Jul;35(7):1360-7. doi: 10.1097/IAE.0000000000000529.
To report the frequency of choroidal neovascularization (CNV) in Caucasian patients with chronic central serous chorioretinopathy (CSC).
Retrospective consecutive series of 272 eyes (136 patients) who were diagnosed as having chronic CSC based on clinical and multimodal fundus imaging findings and documented disease activity for at least 6 months. The CNVs were mainly determined by indocyanine-green angiography.
Patients were evaluated and followed for a maximum of 6 years, with an average follow-up of 14 ± 12 months. Distinct CNV was identified in 41 eyes (34 patients). Based on fluorescein angiography, 37 eyes showed occult with no classic CNV, 3 eyes showed predominantly classic and 1 eye had a disciform CNV. Furthermore, indocyanine-green angiography revealed polypoidal choroidal vasculopathy lesions, in 27 of the 37 eyes, classified as occult CNV on fluorescein angiography. In total, 17.6% of our patients with chronic CSC were found to have CNV that upon indocyanine-green angiography were recognized as being polypoidal choroidal vasculopathy.
In our series of Caucasian patients, we found a significant correlation between chronic CSC and CNV, in which the majority of patients with CNV were found to have polypoidal choroidal vasculopathy. Our findings suggest that indocyanine-green angiography is an indispensable tool in the investigation of chronic CSC.
报告白种人慢性中心性浆液性脉络膜视网膜病变（CSC）患者脉络膜新生血管（CNV）的发生率。
回顾性连续纳入272只眼（136例患者），这些患者根据临床和多模式眼底成像结果被诊断为慢性CSC，且疾病活动记录至少6个月。CNV主要通过吲哚菁绿血管造影确定。
对患者进行评估并随访最长6年，平均随访14±12个月。41只眼（34例患者）发现有明显的CNV。根据荧光素血管造影，37只眼显示隐匿性且无典型CNV，3只眼主要显示为典型CNV，1只眼有盘状CNV。此外，吲哚菁绿血管造影在37只眼中的27只眼中发现了息肉样脉络膜血管病变，这些病变在荧光素血管造影上被归类为隐匿性CNV。在我们的慢性CSC患者中，总共17.6%被发现有CNV，经吲哚菁绿血管造影证实为息肉样脉络膜血管病变。
在我们的白种人患者系列中，我们发现慢性CSC与CNV之间存在显著相关性，其中大多数有CNV的患者被发现患有息肉样脉络膜血管病变。我们的研究结果表明，吲哚菁绿血管造影是慢性CSC检查中不可或缺的工具。
