Yeo Joon Hyung, Oh Richul, Kim Yoon Jeon, Kim June-Gone, Yoon Young Hee, Lee Joo Yong
Department of Ophthalmology, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Republic of Korea.
J Ophthalmol. 2020 Feb 7;2020:7217906. doi: 10.1155/2020/7217906. eCollection 2020.
To identify the clinical characteristics and risk factors for secondary choroidal neovascularization (CNV) in central serous chorioretinopathy (CSC).
In this retrospective study, we included a total of 108 eyes in 106 CSC patients. Group A was defined as patients initially diagnosed with CSC who developed secondary CNV, and group B was defined as patients who did not develop secondary CNV. Clinical and demographic characteristics, optical coherence tomography (OCT) findings at CSC diagnosis and OCT angiography (OCTA) at the time of secondary CNV diagnosis, were compared between the groups.
Thirty-one eyes had CNV (group A) and 77 eyes did not (group B). The mean age of group A was higher than that of group B (52.28 ± 6.87 vs. 46.78 ± 9.45 years; < 0.001). Although there was no difference in pigment epithelial detachment (PED) height, group A had larger PED width than group B at CSC diagnosis. The foveal and parafoveal choriocapillary flow densities were significantly lower in group A than group B ( < 0.001). Although there was no difference in pigment epithelial detachment (PED) height, group A had larger PED width than group B at CSC diagnosis. The foveal and parafoveal choriocapillary flow densities were significantly lower in group A than group B ( < 0.001). Although there was no difference in pigment epithelial detachment (PED) height, group A had larger PED width than group B at CSC diagnosis. The foveal and parafoveal choriocapillary flow densities were significantly lower in group A than group B (.
We identified that older age, wider PED width at diagnosis, and recurrent episodes of CSC were independent risk factors for development of secondary CNV. Therefore, patients with these risk factors should be monitored to allow early detection and prompt treatment of secondary CNV.
确定中心性浆液性脉络膜视网膜病变（CSC）继发脉络膜新生血管（CNV）的临床特征和危险因素。
在这项回顾性研究中，我们纳入了106例CSC患者的108只眼。A组定义为最初诊断为CSC且发生继发CNV的患者，B组定义为未发生继发CNV的患者。比较两组患者的临床和人口统计学特征、CSC诊断时的光学相干断层扫描（OCT）结果以及继发CNV诊断时的OCT血管造影（OCTA）结果。
31只眼发生了CNV（A组），77只眼未发生（B组）。A组的平均年龄高于B组（52.28±6.87岁 vs. 46.78±9.45岁；P<0.001）。虽然色素上皮脱离（PED）高度无差异，但在CSC诊断时，A组的PED宽度大于B组。A组的黄斑和黄斑旁脉络膜毛细血管血流密度显著低于B组（P<0.001）。虽然色素上皮脱离（PED）高度无差异，但在CSC诊断时，A组的PED宽度大于B组。A组的黄斑和黄斑旁脉络膜毛细血管血流密度显著低于B组（P<0.001）。虽然色素上皮脱离（PED）高度无差异，但在CSC诊断时，A组的PED宽度大于B组。A组的黄斑和黄斑旁脉络膜毛细血管血流密度显著低于B组（P<0.001）。
我们确定年龄较大、诊断时PED宽度较宽以及CSC复发是继发CNV发生的独立危险因素。因此，应对具有这些危险因素的患者进行监测，以便早期发现并及时治疗继发CNV。
