Rolinski Michal, Griffanti Ludovica, Szewczyk-Krolikowski Konrad, Menke Ricarda A L, Wilcock Gordon K, Filippini Nicola, Zamboni Giovanna, Hu Michele T M, Mackay Clare E
Oxford Parkinson's Disease Centre (OPDC), Oxford, UK ; Nuffield Department of Clinical Neurosciences, Oxford, UK.
Nuffield Department of Clinical Neurosciences, Oxford, UK ; Centre for the Functional MRI of the Brain (FMRIB), Oxford, UK.
Neuroimage Clin. 2015 Apr 9;8:126-32. doi: 10.1016/j.nicl.2015.04.003. eCollection 2015.
Resting state functional MRI (rs-fMRI) has been previously shown to be a promising tool for the assessment of early Parkinson's disease (PD). In order to assess whether changes within the basal ganglia network (BGN) are disease specific or relate to neurodegeneration generally, BGN connectivity was assessed in 32 patients with early PD, 19 healthy controls and 31 patients with Alzheimer's disease (AD). Voxel-wise comparisons demonstrated decreased connectivity within the basal ganglia of patients with PD, when compared to patients with AD and healthy controls. No significant changes within the BGN were seen in AD, when compared to healthy controls. Moreover, measures of functional connectivity extracted from regions within the basal ganglia were significantly lower in the PD group. Consistent with previous radiotracer studies, the greatest change when compared to the healthy control group was seen in the posterior putamen of PD subjects. When combined into a single component score, this method differentiated PD from AD and healthy control subjects, with a diagnostic accuracy of 81%. Rs-fMRI can be used to demonstrate the aberrant functional connectivity within the basal ganglia of patients with early PD. These changes are likely to be representative of patho-physiological basal ganglia dysfunction and are not associated with generalised neurodegeneration seen in AD. Further studies are necessary to ascertain whether this method is sensitive enough to detect basal ganglia dysfunction in prodromal PD, and its utility as a potential diagnostic biomarker for premotor and early motoric disease.
静息态功能磁共振成像（rs-fMRI）先前已被证明是评估早期帕金森病（PD）的一种有前景的工具。为了评估基底神经节网络（BGN）内的变化是疾病特异性的还是通常与神经退行性变有关，对32例早期PD患者、19例健康对照者和31例阿尔茨海默病（AD）患者的BGN连通性进行了评估。体素水平的比较表明，与AD患者和健康对照者相比，PD患者基底神经节内的连通性降低。与健康对照者相比，AD患者的BGN内未见明显变化。此外，PD组从基底神经节区域提取的功能连通性测量值显著较低。与先前的放射性示踪剂研究一致，与健康对照组相比，PD患者的最大变化出现在后壳核。当合并为单个成分评分时，该方法可区分PD与AD及健康对照者，诊断准确率为81%。Rs-fMRI可用于显示早期PD患者基底神经节内异常的功能连通性。这些变化可能代表了病理生理状态下的基底神经节功能障碍，与AD中所见的全身性神经退行性变无关。有必要进一步研究以确定该方法是否足够敏感以检测前驱期PD中的基底神经节功能障碍，以及其作为运动前和早期运动疾病潜在诊断生物标志物的效用。
