Tsintou Magdalini, Dalamagkas Kyriakos, Seifalian Alexander Marcus
UCL Centre for Nanotechnology & Regenerative Medicine, Division of Surgery and Interventional Science, University College of London, London, UK.
UCL Centre for Nanotechnology & Regenerative Medicine, Division of Surgery and Interventional Science, University College of London, London, UK ; Royal Free London NHS Foundation Trust Hospital, London, UK.
Neural Regen Res. 2015 May;10(5):726-42. doi: 10.4103/1673-5374.156966.
Spinal cord injury results in the permanent loss of function, causing enormous personal, social and economic problems. Even though neural regeneration has been proven to be a natural mechanism, central nervous system repair mechanisms are ineffective due to the imbalance of the inhibitory and excitatory factors implicated in neuroregeneration. Therefore, there is growing research interest on discovering a novel therapeutic strategy for effective spinal cord injury repair. To this direction, cell-based delivery strategies, biomolecule delivery strategies as well as scaffold-based therapeutic strategies have been developed with a tendency to seek for the answer to a combinatorial approach of all the above. Here we review the recent advances on regenerative/neural engineering therapies for spinal cord injury, aiming at providing an insight to the most promising repair strategies, in order to facilitate future research conduction.
脊髓损伤会导致功能永久性丧失，引发巨大的个人、社会和经济问题。尽管神经再生已被证明是一种自然机制，但由于参与神经再生的抑制性和兴奋性因子失衡，中枢神经系统修复机制无效。因此，对于发现有效的脊髓损伤修复新治疗策略的研究兴趣日益浓厚。朝着这个方向，已经开发了基于细胞的递送策略、生物分子递送策略以及基于支架的治疗策略，倾向于寻求上述所有方法的组合方式的答案。在此，我们综述了脊髓损伤再生/神经工程治疗的最新进展，旨在深入了解最有前景的修复策略，以促进未来的研究开展。
