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霍香蓟乙醇提取物对人鼻咽癌细胞具有诱导凋亡和抗增殖作用。

Ethanolic Extracts of Pluchea indica Induce Apoptosis and Antiproliferation Effects in Human Nasopharyngeal Carcinoma Cells.

作者信息

Kao Chiu-Li, Cho Joshua, Lee Ya-Zhe, Cheng Yuan-Bin, Chien Chih-Yen, Hwang Chung-Feng, Hong Yi-Ren, Tseng Chao-Neng, Cho Chung-Lung

机构信息

Department of Biological Sciences, National Sun Yat-sen University, Kaohsiung 80424, Taiwan.

Department of Nursing, Tzu Hui Institute of Technology, Ping-Tung County 92641, Taiwan.

出版信息

Molecules. 2015 Jun 22;20(6):11508-23. doi: 10.3390/molecules200611508.

DOI:10.3390/molecules200611508
PMID:26111179
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6272159/
Abstract

Pluchea indica is used in traditional medicine for the treatment of lumbago, ulcer, tuberculosis and inflammation. The anti-cancer activities and the underlying molecular mechanisms of the ethanolic extracts of P. indica root (PIRE) were characterized in the present study. PIRE strongly inhibited the viability of the human nasopharyngeal carcinoma cells (NPC-TW 01 and NPC-TW 04) in a time- and dose-dependent manner. Migration of cancer cells was also suppressed by PIRE. In addition, PIRE significantly increased the occurrence of the cells in sub-G1 phase and the extent of DNA fragmentation in a dose-dependent manner, which indicates that PIRE significantly increased apoptosis in NPC cells. The apoptotic process triggered by PIRE involved up-regulation of pro-apoptotic Bax protein and down-regulation of anti-apoptotic Bcl-2 protein, consequently increasing the ratios of Bax/Bcl-2 protein levels. Moreover, the p53 protein was up-regulated by PIRE in a concentration-dependent manner. Therefore, PIRE could induce the apoptosis-signaling pathway in NPC cells by activation of p53 and by regulation of apoptosis-related proteins.

摘要

咸虾花在传统医学中用于治疗腰痛、溃疡、肺结核和炎症。本研究对咸虾花根乙醇提取物（PIRE）的抗癌活性及其潜在分子机制进行了表征。PIRE以时间和剂量依赖性方式强烈抑制人鼻咽癌细胞（NPC-TW 01和NPC-TW 04）的活力。癌细胞的迁移也受到PIRE的抑制。此外，PIRE以剂量依赖性方式显著增加亚G1期细胞的发生率和DNA片段化程度，这表明PIRE显著增加了NPC细胞中的凋亡。PIRE触发的凋亡过程涉及促凋亡Bax蛋白的上调和抗凋亡Bcl-2蛋白的下调，从而增加了Bax/Bcl-2蛋白水平的比率。此外，PIRE以浓度依赖性方式上调p53蛋白。因此，PIRE可通过激活p53和调节凋亡相关蛋白来诱导NPC细胞中的凋亡信号通路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/be6573b57eab/molecules-20-11508-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/b39219cf44e0/molecules-20-11508-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/082dc9d570a7/molecules-20-11508-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/5a4727e3c5ef/molecules-20-11508-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/11b73adfda14/molecules-20-11508-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/6a734e21265d/molecules-20-11508-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/be6573b57eab/molecules-20-11508-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/b39219cf44e0/molecules-20-11508-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/082dc9d570a7/molecules-20-11508-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/5a4727e3c5ef/molecules-20-11508-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/11b73adfda14/molecules-20-11508-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/6a734e21265d/molecules-20-11508-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4737/6272159/be6573b57eab/molecules-20-11508-g006.jpg

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