Gillespie J S, Liu X R, Martin W
Department of Pharmacology, University of Glasgow.
Br J Pharmacol. 1989 Dec;98(4):1080-2. doi: 10.1111/j.1476-5381.1989.tb12650.x.
The effect of the competitive inhibitor of L-arginine, NG-monomethyl L-arginine (L-NMMA) on the response of the rat anococcygeus muscle to non-adrenergic, non-cholinergic (NANC) inhibitory nerve stimulation has been examined. L-NMMA causes a rise in muscle tone and inhibition of the response to nerve stimulation. The stereoisomer D-NMMA is without effect. The rise in tone and inhibition of the nerve response is reversed by L-arginine. Another analogue, L-canavanine, which is effective against L-arginine utilization in the macrophage, was without effect on the rat anococcygeus. These results provide indirect evidence for nitric oxide (NO) or a substance releasing NO as the transmitter of the NANC nerves in this tissue.
已研究了L - 精氨酸的竞争性抑制剂NG - 单甲基L - 精氨酸（L - NMMA）对大鼠肛门尾骨肌对非肾上腺素能、非胆碱能（NANC）抑制性神经刺激反应的影响。L - NMMA可导致肌张力升高并抑制对神经刺激的反应。立体异构体D - NMMA则无此作用。L - 精氨酸可逆转肌张力升高和神经反应抑制。另一种类似物L - 刀豆氨酸对巨噬细胞中L - 精氨酸的利用有效，但对大鼠肛门尾骨肌无作用。这些结果为一氧化氮（NO）或释放NO的物质作为该组织中NANC神经的递质提供了间接证据。
