人α-和β-降钙素基因相关肽对清醒Wistar大鼠的局部血流动力学影响

Regional haemodynamic effects of human alpha- and beta-calcitonin gene-related peptide in conscious Wistar rats.

Gardiner S M, Compton A M, Bennett T

Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham.

Br J Pharmacol. 1989 Dec;98(4):1225-32. doi: 10.1111/j.1476-5381.1989.tb12668.x.

A comparative study was carried out to assess the regional haemodynamic effects of intravenous infusion of human alpha- and beta-calcitonin gene-related peptide (CGRP; 0.006, 0.06 and 0.6 nmol h-1) in conscious, unrestrained Wistar rats. 2. With human alpha-CGRP, tachycardia was always accompanied by a fall in mean arterial blood pressure (MBP), but human beta-CGRP at the middle dose caused tachycardia with no significant hypotension. 3. Human alpha- and beta-CGRP both caused dose-dependent falls in MBP accompanied by common carotid and hindquarters vasodilatations and increased flows. The highest dose of alpha- and beta-CGRP caused mesenteric vasoconstriction and renal vasodilatation, but the latter was not associated with an increase in flow. 4. With the intermediate dose, human alpha-CGRP caused more significant haemodynamic changes than did human beta-CGRP. In addition, comparison with previous experiments involving infusion of rat alpha-CGRP indicated that human alpha-CGRP had more potent haemodynamic effects than the former.

开展了一项比较研究，以评估静脉输注人α-和β-降钙素基因相关肽（CGRP；0.006、0.06和0.6 nmol h-1）对清醒、未束缚的Wistar大鼠的局部血流动力学影响。2. 对于人α-CGRP，心动过速总是伴随着平均动脉血压（MBP）下降，但中剂量的人β-CGRP引起心动过速且无明显低血压。3. 人α-和β-CGRP均导致MBP呈剂量依赖性下降，同时伴有颈总动脉和后肢血管扩张及血流量增加。α-和β-CGRP的最高剂量引起肠系膜血管收缩和肾血管扩张，但后者与血流量增加无关。4. 使用中间剂量时，人α-CGRP比人β-CGRP引起更显著的血流动力学变化。此外，与先前涉及输注大鼠α-CGRP的实验相比，表明人α-CGRP的血流动力学效应比前者更强。

Regional haemodynamic effects of human alpha- and beta-calcitonin gene-related peptide in conscious Wistar rats.