羟基导向交叉偶联：去溴哈米格尔烷E及其他相关目标化合物的可扩展合成
Hydroxyl-Directed Cross-Coupling: A Scalable Synthesis of Debromohamigeran E and Other Targets of Interest.
作者信息
Blaisdell Thomas P, Morken James P
机构信息
Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467, United States.
出版信息
J Am Chem Soc. 2015 Jul 15;137(27):8712-5. doi: 10.1021/jacs.5b05477. Epub 2015 Jul 2.
Abstract
A hydroxyl functional group positioned β to a pinacol boronate can serve to direct palladium-catalyzed cross-coupling reactions. This feature can be used to control the reaction site in multiply borylated substrates and can activate boronates for reaction that would otherwise be unreactive.
摘要
位于频哪醇硼酸酯β位的羟基官能团可用于指导钯催化的交叉偶联反应。这一特性可用于控制多硼酸化底物中的反应位点，并可激活硼酸酯以进行否则将无反应性的反应。
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