CCR6与类风湿关节炎之间的关联：一项荟萃分析。
Association between CCR6 and rheumatoid arthritis: a meta-analysis.
作者信息
Cheng Peng, Zhang Ying, Huang Hui, Zhang Weikai, Yang Qing, Guo Fengjing, Chen Anmin
机构信息
Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430030, P. R. China.
Department of Nephrology, Tongji Hospital, Tongji Medical College, Huazhong University of Science And Technology Wuhan 430030, P. R. China.
出版信息
Int J Clin Exp Med. 2015 Apr 15;8(4):5388-96. eCollection 2015.
OBJECTIVE
Chemokine (C-C motif) receptor 6 gene (CCR6) polymorphism has been reported to be associated with rheumatoid arthritis (RA) in different ethnic populations. Moreover, its inhibition by monoclonal antibody in mouse model has suppressed arthritis. However, few replication studies have reported conflicting results about this association. Therefore, to establish that CCR6 indeed is a risk factor associated with RA among different ethnic populations, a comprehensive meta-analysis study was conducted.
METHODS
PubMed and MEDLINE databases were searched using the term 'CCR6' for all articles published before May 2014. All the replication studies examining the association between CCR6 and RA were reviewed for meta-analysis. Data were summarized using random-effects meta-analysis. The heterogeneity and publication bias among studies were examined by χ(2) -based Q statistic test and Egger's test, respectively.
RESULTS
A total of 24955 RA patients and 56129 controls from seven articles were included in the meta-analysis. While CCR6 was a risk factor in Asian (OR = 1.19, 95% CI: 1.14-1.24) and European (OR = 1.14, 95% CI: 1.08-1.21) populations, it was indicated as a protective factor in African Americans (OR = 0.79, 95% CI: 0.62-0.96).
CONCLUSIONS
Our meta-analysis study concludes that there is a significant association between CCR6 and RA in all racial groups except African-American subgroup, which require a large sample size for concrete prediction.
目的
据报道，趋化因子（C-C基序）受体6基因（CCR6）多态性在不同种族人群中与类风湿关节炎（RA）相关。此外，在小鼠模型中，其单克隆抗体抑制作用可抑制关节炎。然而，很少有重复研究报道该关联存在相互矛盾的结果。因此，为证实CCR6确实是不同种族人群中与RA相关的危险因素，开展了一项全面的荟萃分析研究。
方法
使用“CCR6”一词在PubMed和MEDLINE数据库中检索2014年5月之前发表的所有文章。对所有检验CCR6与RA之间关联的重复研究进行综述以进行荟萃分析。采用随机效应荟萃分析汇总数据。分别通过基于χ(2)的Q统计检验和Egger检验来检验研究间的异质性和发表偏倚。
结果
荟萃分析纳入了来自7篇文章的总共24955例RA患者和56129例对照。虽然CCR6在亚洲人群（比值比[OR]=1.19，95%置信区间[CI]：1.14 - 1.24）和欧洲人群（OR = 1.14，95% CI：1.08 - 1.21）中是危险因素，但在非裔美国人中它被表明是保护因素（OR = 0.79，95% CI：0.62 - 0.96）。
结论
我们的荟萃分析研究得出结论，除了非裔美国人亚组外，CCR6与所有种族组的RA之间均存在显著关联，这需要大样本量才能进行具体预测。
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