Park Hyun Kyung, Kim Su Kang, Kweon Hae Yong, Lee Kwan Gill, Arasu Mariadhas Valan, Kim Young Ock
Department of Emergency Medicine, School of Medicine, Kyung Hee University, Seoul 05728, Republic of Korea.
Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Saudi J Biol Sci. 2017 Feb;24(2):444-449. doi: 10.1016/j.sjbs.2016.01.013. Epub 2016 Jan 11.
Rheumatoid arthritis (RA) is a chronic disease. It causes chronic inflammation of the joint. Recent studies suggested that interleukin 4 (IL4) contributes to susceptibility and severity of rheumatoid arthritis (RA). Especially, it was reported that promoter polymorphism (-590, T/C) of gene has been associated with susceptibility of RA. The aim of present study was to investigate whether the promoter polymorphism (-590, T/C) of gene is associated with the susceptibility of RA using meta-analysis. And in order to perform meta-analysis, comprehensive meta analysis program was used. Genetic models (co-dominant, dominant, recessive, and allele) were used to determine odds ratios (ORs), 95% confidence intervals (CIs), and values. Nine case-control studies with case and control design were included in this meta-analysis. Overall, meta-analysis revealed a strong association with susceptibility of RA [OR = 1.303, 95% CI = 1.093-1.554, = 0.003 in allele model (C vs. T); OR = 1.247, 95% CI = 1.054-1.474, = 0.010 in dominant model (CC vs. CT + TT); OR = 2.148, 95% CI = 1.263-3.651, = 0.005 in recessive model (CC + CT vs. TT)]. Our data demonstrated that promoter polymorphism (-590, T/C) of gene may be contributed to susceptibility of RA. However, more studies with a larger sample size are needed to provide more precise evidence.
类风湿性关节炎（RA）是一种慢性疾病。它会导致关节的慢性炎症。最近的研究表明，白细胞介素4（IL4）与类风湿性关节炎（RA）的易感性和严重程度有关。特别是，有报道称该基因的启动子多态性（-590，T/C）与RA的易感性相关。本研究的目的是通过荟萃分析来调查该基因的启动子多态性（-590，T/C）是否与RA的易感性相关。为了进行荟萃分析，使用了综合荟萃分析程序。采用遗传模型（共显性、显性、隐性和等位基因）来确定比值比（OR）、95%置信区间（CI）和P值。本荟萃分析纳入了9项采用病例对照设计的病例对照研究。总体而言，荟萃分析显示与RA的易感性有很强的关联[等位基因模型（C与T）中，OR = 1.303，95% CI = 1.093 - 1.554，P = 0.003；显性模型（CC与CT + TT）中，OR = 1.247，95% CI = 1.054 - 1.474，P = 0.010；隐性模型（CC + CT与TT）中，OR = 2.148，95% CI = 1.263 - 3.651，P = 0.005]。我们的数据表明该基因的启动子多态性（-590，T/C）可能与RA的易感性有关。然而，需要更多样本量更大的研究来提供更精确的证据。
