Hu Liang-Hao, Ji Jun-Tao, Li Zhao-Shen
Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
J Cell Mol Med. 2015 Sep;19(9):2049-57. doi: 10.1111/jcmm.12603. Epub 2015 Jul 6.
Chronic pancreatitis (CP) is a progressive inflammatory disease typified by end-stage fibrosis. This disease can also increase the risk of pancreatic cancer. The associated diagnosis, pain and other complications further add to the burden of disease management. In recent years, significant progress has been achieved in identifying miRNAs and their physiological functions, including mRNA repression and protein expression control. Given the extensive effort made on miRNA research, a close correlation has been discovered between certain types of miRNAs and disease progression, particularly for tissue fibrosis. Designing miRNA-related tools for disease diagnosis and therapeutic treatments presents a novel and potential research frontier. In the current review, we discuss various miRNAs closely interacting with CP, as well as the possible development of targeted miRNA therapies in managing this disease.
慢性胰腺炎（CP）是一种以终末期纤维化为特征的进行性炎症性疾病。这种疾病还会增加患胰腺癌的风险。相关的诊断、疼痛及其他并发症进一步加重了疾病管理的负担。近年来，在鉴定微小RNA（miRNA）及其生理功能方面取得了重大进展，包括mRNA抑制和蛋白质表达控制。鉴于在miRNA研究方面付出的巨大努力，已发现某些类型的miRNA与疾病进展密切相关，尤其是对于组织纤维化。设计与miRNA相关的疾病诊断和治疗工具是一个新的潜在研究前沿。在本综述中，我们讨论了与慢性胰腺炎密切相关的各种miRNA，以及在管理这种疾病中靶向miRNA治疗的可能进展。
