Paiva Tiago O, Almeida Pedro R, Ferreira-Santos Fernando, Vieira Joana B, Silveira Celeste, Chaves Pedro L, Barbosa Fernando, Marques-Teixeira João
Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences of the University of Porto, Portugal; Faculty of Medicine of the University of Porto, Portugal.
Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences of the University of Porto, Portugal; School of Criminology, Faculty of Law of the University of Porto, Portugal.
Clin Neurophysiol. 2016 Jan;127(1):499-508. doi: 10.1016/j.clinph.2015.06.016. Epub 2015 Jun 26.
The literature suggests that the N1 and P2 waves of the auditory ERP are dissociable at the developmental, experimental, and source levels. At the experimental level, inconsistent findings suggest different effects of intensity on the amplitudes of the auditory N1 and P2. Our main goal was to analyze the intensity dependence of the auditory N1 and P2 while controlling for habituation effects.
We examined the intensity dependence of both averaged and single-trial auditory N1 and P2 waves elicited in a repeated-stimulation protocol.
N1 and P2 revealed similar intensity dependence on both standard and filter denoised ERP, with a linear tendency for higher intensities to elicit higher absolute peak amplitudes. At the single-trial level, both waves covary irrespective of stimulus intensity and trial order.
Our results suggest that stimulus intensity variation induces similar effects on both and N1 and P2 and partially contradict previous data that classified the P2 as a non-habituating component.
Our findings contribute to the ongoing discussion on the functional significance of the auditory P2 deflection. In addition, the present work demonstrated the applicability of a filter denoising method for single-trial estimation in the analysis of the experimental effects on auditory ERP components.
文献表明，听觉事件相关电位的N1和P2波在发育、实验和源水平上是可分离的。在实验水平上，不一致的研究结果表明强度对听觉N1和P2波幅有不同影响。我们的主要目标是在控制习惯化效应的同时分析听觉N1和P2的强度依赖性。
我们在重复刺激方案中检测了平均和单次试验诱发的听觉N1和P2波的强度依赖性。
N1和P2在标准和滤波去噪的事件相关电位上显示出相似的强度依赖性，强度越高，绝对峰值波幅越高，呈线性趋势。在单次试验水平上，无论刺激强度和试验顺序如何，两个波都协变。
我们的结果表明，刺激强度变化对N1和P2都有相似的影响，这部分与之前将P2归类为非习惯化成分的数据相矛盾。
我们的发现有助于正在进行的关于听觉P2偏转功能意义的讨论。此外，本研究证明了滤波去噪方法在单次试验估计中的适用性，可用于分析对听觉事件相关电位成分的实验效应。
