Ardila Carlos M, Perez-Valencia Aide-Yancelly, Rendon-Osorio Willer-Leandro
Periodontist. Ph.D in Epidemiology, Biomedical Stomatology Group, Universidad de Antioquia U de A, Medellín, Colombia, Department of Periodontology, School of Dentistry, Universidad de Antioquia.
Dentist, Department of Periodontology, School of Dentistry, Universidad de Antioquia.
J Clin Exp Dent. 2015 Apr 1;7(2):e254-60. doi: 10.4317/jced.52128. eCollection 2015 Apr.
Accumulating evidence suggests that acute and chronic infections with periodontopathogens are associated with an increased risk of cardiovascular disease. The objective of this study was to assess whether Tanerella forsythia and Porphyromonas gingivalis are associated with increased levels of atherogenic low-density lipoprotein (LDL), high-density lipoprotein, total cholesterol (TC), triglycerides and body mass index (BMI) in chronic periodontitis patients.
Medical history and clinical and radiographic examination were conducted in 80 chronic periodontitis patients and 28 healthy individuals. Fasting blood samples were drawn for the measurement of the parameters of dyslipidemia. Anthropometric measurements such as height in meters and weight in kilograms were recorded. Both periodontitis and control subjects were asked to answer a questionnaire with regard to their socio-demographic and smoking status. The presence of T. forsythia, and P. gingivalis was detected using primers designed to target the respective 16S rRNA gene sequences.
The occurrence of T. forsythia and P. gingivalis was higher in the group of subjects with periodontitis. Superior levels of triglycerides were observed in chronic periodontitis patients compared to healthy individuals. High levels of TC in periodontitis persons were significantly associated with increased bleeding on probing. Greater mean levels of TC and LDL were shown in the presence of T. forsythia (P<0.05). Likewise, higher proportions of patients with BMI ≥25 kg/m2 related with T. forsythia (P<0.05). T. forsythia was a significant discriminating factor in the multivariate linear regression model emerging as significant explanatory of increased levels of TC (β=17,879, 95% CI = 4,357-31,401; p=0.01) and LDL (β=17,162, 95% CI= 4,009-30,316; p=0.01).
Higher levels of serum total cholesterol and LDL were observed in the occurrence of T. forsythia and the presence of this periodontopathogen may increase the atherogenic potency of low-density lipoprotein that may augment the risk for atherosclerosis in periodontal disease patients. Key words:Periodontitis, dyslipidemia, Tannerella forsythia, cardiovascular disease.
越来越多的证据表明，牙周病原体的急性和慢性感染与心血管疾病风险增加有关。本研究的目的是评估福赛坦纳菌和牙龈卟啉单胞菌是否与慢性牙周炎患者中致动脉粥样硬化的低密度脂蛋白（LDL）、高密度脂蛋白、总胆固醇（TC）、甘油三酯水平升高以及体重指数（BMI）有关。
对80例慢性牙周炎患者和28例健康个体进行病史、临床及影像学检查。采集空腹血样以测量血脂异常参数。记录身高（米）和体重（千克）等人体测量数据。牙周炎患者和对照组均被要求回答一份关于其社会人口统计学和吸烟状况的问卷。使用针对各自16S rRNA基因序列设计的引物检测福赛坦纳菌和牙龈卟啉单胞菌的存在。
牙周炎患者组中福赛坦纳菌和牙龈卟啉单胞菌的发生率更高。与健康个体相比，慢性牙周炎患者的甘油三酯水平更高。牙周炎患者的高TC水平与探诊出血增加显著相关。在有福赛坦纳菌存在的情况下，TC和LDL的平均水平更高（P<0.05）。同样，BMI≥25 kg/m2的患者中与福赛坦纳菌相关的比例更高（P<0.05）。在多元线性回归模型中，福赛坦纳菌是一个显著的区分因素，可显著解释TC（β=17,879，95% CI = 4,357 - 31,401；p = 0.01）和LDL（β=17,162，95% CI = 4,009 - 30,316；p = 0.01）水平升高。
在有福赛坦纳菌存在的情况下观察到血清总胆固醇和LDL水平较高，这种牙周病原体的存在可能会增加低密度脂蛋白的致动脉粥样硬化能力，从而增加牙周病患者患动脉粥样硬化的风险。关键词：牙周炎、血脂异常、福赛坦纳菌、心血管疾病
