Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Int J Obes (Lond). 2018 Feb;42(2):121-128. doi: 10.1038/ijo.2017.191. Epub 2017 Aug 14.
BACKGROUND/OBJECTIVES: We aimed to determine the alteration of Tannerella forsythia and coating color on the dorsal tongue, and fatty food liking in catch-up fat in adult (CUFA), as well as the probable associations between fat accumulation, insulin resistance (IR) and these changes.
SUBJECTS/METHODS: T. forsythia on the tongue dorsum, fatty food liking, fat accumulation and insulin sensitivity were investigated in CUFA humans and rats, and tongue-coating color was observed in CUFA individuals. We further determined the changes of fatty food liking, fat accumulation and IR in T. forsythia-infected rodents by oral lavage.
Increases in fat accumulation, IR, percentage of subjects with yellow tongue coating and that with T. forsythia detected were observed in CUFA individuals. Additionally, the fat ranking scores were significantly lower and the hedonic ratings of low-fat options of sampled food were lower, while the ratings of high-fat options were remarkably higher in CUFA subjects. Additionally, T. forsythia level elevated in CUFA rats, and fatty food liking, fat accumulation and IR increased in CUFA and T. forsythia-infected animals, with the increases in T. forsythia infection and fatty food liking preceding the occurrence of fat accumulation and IR.
T. forsythia and yellow coating on the dorsal tongue and fatty food liking associate fat accumulation and IR in CUFA. Moreover, we tentatively put forward that T. forsythia, which is very important in yellow tongue-coating microbiota, and its consequent increases in fatty food liking, might be crucial in the development of fat accumulation and IR in CUFA.
背景/目的：我们旨在确定成人追赶性肥胖（CUFA）中坦纳拉福赛氏菌（Tannerella forsythia）和舌背涂层颜色的变化，以及对高脂肪食物的喜好，并探讨脂肪积累、胰岛素抵抗（IR）与这些变化之间可能存在的关联。
受试者/方法：在 CUFA 人群和大鼠中，我们调查了舌背 T. forsythia、对高脂肪食物的喜好、脂肪积累和胰岛素敏感性，同时观察了 CUFA 个体的舌涂层颜色。我们进一步通过口腔灌洗，确定了 T. forsythia 感染啮齿动物中对高脂肪食物的喜好、脂肪积累和 IR 的变化。
CUFA 个体中观察到脂肪积累增加、IR 增加、黄舌苔和 T. forsythia 检出率增加。此外，CUFA 受试者的脂肪排名评分显著降低，对采样食物低脂选项的愉悦评分降低，而对高脂选项的愉悦评分显著升高。此外，CUFA 大鼠中 T. forsythia 水平升高，CUFA 和 T. forsythia 感染动物中对高脂肪食物的喜好、脂肪积累和 IR 增加，T. forsythia 感染和对高脂肪食物的喜好增加先于脂肪积累和 IR 的发生。
T. forsythia 和舌背的黄色涂层以及对高脂肪食物的喜好与 CUFA 中的脂肪积累和 IR 相关。此外，我们推测在黄色舌苔微生物群中非常重要的 T. forsythia 及其随后对高脂肪食物的喜好增加，可能在 CUFA 中脂肪积累和 IR 的发展中起着关键作用。
