Kozarov Emil
Section of Oral & Diagnostic Sciences, Columbia University Medical Center, 630 West 168 Street, P&S Box 20, New York, NY 10032, USA.
Future Cardiol. 2012 Jan;8(1):123-38. doi: 10.2217/fca.11.75.
To portray the chronic inflammation in atherosclerosis, leukocytic cell types involved in the immune response to invading pathogens are often the focus. However, atherogenesis is a complex pathological deterioration of the arterial walls, where vascular cell types are participants with regards to deterioration and disease. Since other recent reviews have detailed the role of both the innate and adaptive immune response in atherosclerosis, herein we will summarize the latest developments regarding the association of bacteria with vascular cell types: infections as a risk factor for atherosclerosis; bacterial invasion of vascular cell types; the atherogenic sequelae of bacterial presence such as endothelial activation and blood clotting; and the identification of the species that are able to colonize this niche. The evidence of a polybacterial infectious component of the atheromatous lesions opens the doors for exploration of the new field of vascular infectology and for the study of atherosclerosis microbiome.
为了描绘动脉粥样硬化中的慢性炎症，参与对入侵病原体免疫反应的白细胞类型常常成为研究重点。然而，动脉粥样硬化形成是动脉壁复杂的病理恶化过程，在此过程中血管细胞类型也是恶化和疾病的参与者。由于近期其他综述已详细阐述了固有免疫和适应性免疫反应在动脉粥样硬化中的作用，因此本文将总结关于细菌与血管细胞类型关联的最新进展：感染作为动脉粥样硬化的危险因素；细菌对血管细胞类型的侵袭；细菌存在导致的动脉粥样硬化后遗症，如内皮激活和血液凝固；以及能够在这个生态位定殖的菌种的鉴定。动脉粥样硬化病变中多细菌感染成分的证据为探索血管感染学新领域以及研究动脉粥样硬化微生物组打开了大门。
