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Effects of three resin monomers on the cellular glutathione concentration of cultured human gingival fibroblasts.三种树脂单体对培养的人牙龈成纤维细胞内谷胱甘肽浓度的影响。
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4
TEGDMA induces mitochondrial damage and oxidative stress in human gingival fibroblasts.三乙二醇二甲基丙烯酸酯可诱导人牙龈成纤维细胞的线粒体损伤和氧化应激。
Biomaterials. 2005 Sep;26(25):5130-7. doi: 10.1016/j.biomaterials.2005.01.014.
5
Direct composite resin restorations: a review of some clinical procedures to achieve predictable results in posterior teeth.直接复合树脂修复：一些在后牙实现可预测效果的临床操作综述。
J Esthet Restor Dent. 2004;16(1):19-31; discussion 32. doi: 10.1111/j.1708-8240.2004.tb00446.x.
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Effects of BisGMA on glutathione metabolism and apoptosis in human gingival fibroblasts in vitro.双甲基丙烯酸缩水甘油酯对体外培养的人牙龈成纤维细胞谷胱甘肽代谢及细胞凋亡的影响
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Resin composite monomers alter MTT and LDH activity of human gingival fibroblasts in vitro.树脂复合材料单体在体外改变人牙龈成纤维细胞的MTT和LDH活性。
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TEGDMA causes apoptosis in primary human gingival fibroblasts.三乙二醇二甲基丙烯酸酯可导致原代人牙龈成纤维细胞凋亡。
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Sublethal, 2-week exposures of dental material components alter TNF-alpha secretion of THP-1 monocytes.牙科材料成分进行为期两周的亚致死性暴露会改变THP-1单核细胞的肿瘤坏死因子-α分泌。
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Biological clearance of HEMA in guinea pigs.豚鼠体内甲基丙烯酸羟乙酯的生物清除率。
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一种牙科商用复合材料的毒性测试。

Toxicity test of a dental commercial composite.

作者信息

Ponce-Bravo Santa, Ledesma-Montes Constantino, Martínez-Rivera José-Luis, Garcés-Ortíz Maricela

机构信息

Oral Pathology Laboratory. División de Estudios de Posgrado e Investigación. Facultad de Odontología, Universidad Nacional Autónoma de México. México, Distrito Federal. MÉXICO.

出版信息

J Clin Exp Dent. 2015 Apr 1;7(2):e289-92. doi: 10.4317/jced.52201. eCollection 2015 Apr.

DOI:10.4317/jced.52201
PMID:26155348
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4483339/
Abstract

BACKGROUND

International rules must be followed for testing biosecurity in dental materials. A new brand of restorative material appeared in the market and regulations indicated that it should be tested for toxicity.

OBJECTIVES

The aim of this study was to determine the 90-day sub chronic toxicity of one triethylene glycol dimethacrylate containing composite (MEDENTAL Light-Cure Composite™) orally administered to rats according to Organization for Economic Co-Operation and Development no. 48 guidelines and the requirements specified in the ISO 10993-11.

MATERIAL AND METHODS

Wistar rats ate the polymerized composite during 90 days and were observed to determine changes in their behavior, eye and skin signs and other attitudes such as aggressiveness, posture, walking and response to handling. After 90 days were sacrificed to ascertain blood alterations, we did special hematological tests and assessed microscopic slides from 33 different organs.

RESULTS

We recorded no significant changes in clinical behavior of the animals. Microscopic review of the H&E stained slides obtained from the analyzed organs showed no abnormal inflammatory or cytological changes and all hematological special tests were within normal limits.

CONCLUSIONS

Results of this study show that under our experimental conditions the MEDENTAL Light-Cure Composite™ does not produce inflammatory or cytological changes suggestive of toxicity. Key words:Dental materials, composite resin, toxicity, inflammation, TEGDMA.

摘要

背景

在对牙科材料进行生物安全性测试时必须遵循国际规则。市场上出现了一种新型修复材料，法规规定应对其进行毒性测试。

目的

本研究的目的是根据经济合作与发展组织第48号指南以及ISO 10993-11规定的要求，确定口服给予大鼠的一种含二缩三乙二醇二甲基丙烯酸酯的复合材料（MEDENTAL光固化复合材料™）的90天亚慢性毒性。

材料与方法

Wistar大鼠连续90天食用聚合后的复合材料，并对其行为、眼部和皮肤体征以及其他行为表现（如攻击性、姿势、行走和对处理的反应）进行观察。90天后将大鼠处死以确定血液变化，我们进行了特殊的血液学检测，并对33个不同器官的显微切片进行了评估。

结果

我们记录到动物的临床行为没有显著变化。对从分析器官获得的苏木精和伊红染色切片进行显微镜检查，未发现异常炎症或细胞学变化，所有血液学特殊检测结果均在正常范围内。

结论

本研究结果表明，在我们的实验条件下，MEDENTAL光固化复合材料™不会产生提示毒性的炎症或细胞学变化。关键词：牙科材料、复合树脂、毒性、炎症、TEGDMA