Yorulmaz Ahu, Artuz Ferda, Er Olcay, Guresci Servet
Ankara Numune Research and Training Hospital.
Dermatol Online J. 2015 Jun 16;21(6):13030/qt7gj157xg.
Graham-Little-Piccardi-Lasseur Syndrome (GLPLS) is a variant of lichen planopilaris, which is characterized by progressive cicatricial alopecia of scalp, non-cicatricial alopecia of axillae and pubic regions, and keratosis pilaris-like follicular papules over trunk and extremities. GLPLS is a disease of unknown etiology. However, recent reports support a central role for a T-cell-mediated immune response in the pathogenesis of GLPLS. Besides, although GLPLS is believed to occur sporadically, a genetic predisposition also has been implicated in the pathogenesis. On the other hand, GLPLS typically affects middle-aged women, particularly of the postmenopausal age group. A diagnosis of GLPLS is generally apparent with the presence of characteristic findings in a postmenopausal woman. Herein, we report a case of GLPLS in a 75-year-old woman with the typical triad of alopecia of the scalp, non-cicatricial alopecia of axillae and pubis, and a follicular keratotic eruption on the trunk.
格雷厄姆-利特尔-皮卡迪-拉瑟尔综合征（GLPLS）是扁平苔藓样毛发角化病的一种变体，其特征为头皮进行性瘢痕性脱发、腋窝和耻骨区非瘢痕性脱发，以及躯干和四肢出现毛发角化病样毛囊丘疹。GLPLS是一种病因不明的疾病。然而，最近的报告支持T细胞介导的免疫反应在GLPLS发病机制中起核心作用。此外，尽管GLPLS被认为是散发性发生，但遗传易感性也被认为与发病机制有关。另一方面，GLPLS通常影响中年女性，尤其是绝经后年龄组。在绝经后女性中出现特征性表现时，GLPLS的诊断通常很明显。在此，我们报告一例75岁女性的GLPLS病例，其具有典型的三联征，即头皮脱发、腋窝和耻骨区非瘢痕性脱发以及躯干毛囊角化性皮疹。
