Ambur Austin, Bhukhan Aashni, Dunn Charles, Nathoo Rajiv
Department of Dermatology, Kansas City University, Kansas, Florida, USA.
Int J Trichology. 2023 Jul-Aug;15(4):154-156. doi: 10.4103/ijt.ijt_47_22. Epub 2024 Apr 5.
Graham-Little-Piccardi-Lasseur syndrome (GLPLS) is characterized by diffuse alopecia and a lichenoid follicular eruption affecting the scalp, eyebrows, and intertriginous regions. It is considered a variant of lichen planopilaris. The condition often begins as hyperkeratotic papules on the trunk and extremities followed by the development of alopecia. Several subtypes of lichen planus have been associated with a photodistriubuted eruption including lichenoid drug reactions, actinic lichen planus, and lichen planus pigmentosus; however, there are no reported cases associated with GLPLS. We herein report the first case of GLPLS displaying a photodistributed lichenoid eruption to expand upon the differential diagnosis of photoaggravated conditions. We also use this case to review the pathophysiology and therapeutic modalities to manage GLPLS.
格雷厄姆-利特尔-皮卡迪-拉瑟尔综合征（GLPLS）的特征是弥漫性脱发以及影响头皮、眉毛和间擦部位的苔藓样毛囊疹。它被认为是扁平苔藓性毛囊炎的一种变体。该病通常始于躯干和四肢的角化过度丘疹，随后出现脱发。扁平苔藓的几种亚型与光分布性皮疹有关，包括苔藓样药物反应、光化性扁平苔藓和色素性扁平苔藓；然而，尚无与GLPLS相关的报道病例。我们在此报告首例表现为光分布性苔藓样皮疹的GLPLS病例，以拓展对光加重性疾病的鉴别诊断。我们还利用该病例回顾了GLPLS的病理生理学和治疗方法。
