Abbas Ossama, Chedraoui Adele, Ghosn Samer
Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon.
J Am Acad Dermatol. 2007 Aug;57(2 Suppl):S15-8. doi: 10.1016/j.jaad.2006.11.010.
Frontal fibrosing alopecia (FFA), a cicatricial alopecia of the frontoparietal hairline affecting mainly postmenopausal women, is commonly associated with nonscarring alopecia of the eyebrows. This association has led some authors to relate it to Piccardi-Lassueur-Graham-Little syndrome (PLGLS), which is characterized by the triad of multifocal scalp cicatricial alopecia, nonscarring alopecia of the axillae and/or groin, and keratotic follicular papules. This is in spite of the absence of the follicular keratotic papules typical of PLGLS, and the different patterns of the cicatricial alopecias. We report a 37-year-old premenopausal woman with FFA associated with nonscarring alopecia of the eyebrows and axillae and follicular lichen planus-like lesions of the face. This case illustrates that FFA and PLGLS may share characteristics that, in addition to the overlap between FFA and PLGLS reported in the literature, would suggest they may be phenotypically related.
额部纤维性秃发（FFA）是一种主要影响绝经后女性的额顶部发际线瘢痕性秃发，通常与非瘢痕性眉毛秃发相关。这种关联使得一些作者将其与皮卡迪-拉叙厄尔-格雷厄姆-利特尔综合征（PLGLS）联系起来，该综合征的特征为多灶性头皮瘢痕性秃发、腋窝和/或腹股沟非瘢痕性秃发以及角化性毛囊丘疹三联征。尽管该病例缺乏PLGLS典型的毛囊角化性丘疹，且瘢痕性秃发的模式也不同。我们报告了一名37岁的绝经前女性，患有FFA，伴有眉毛和腋窝非瘢痕性秃发以及面部毛囊扁平苔藓样病变。该病例表明，FFA和PLGLS可能具有共同特征，除了文献中报道的FFA和PLGLS之间的重叠外，还提示它们可能在表型上相关。
