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格雷厄姆-利特尔-皮卡迪-拉叙厄尔综合征及文献综述

Graham-Little Piccardi Lassueur syndrome and review of the literature.

作者信息

Alkhayal Fares A, Alsudairy Fahad, Al Mubarak Luluah, Almohanna Hind M

机构信息

Dermatology and Dermatologic Surgery Department Prince Sultan Military Medical City Riyadh Saudi Arabia.

出版信息

Clin Case Rep. 2021 Sep 5;9(9):e04761. doi: 10.1002/ccr3.4761. eCollection 2021 Sep.

DOI:10.1002/ccr3.4761
PMID:34504697
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8418680/
Abstract

Graham-Little Piccardi Lassueur Syndrome (GLPLS) is a rare variant of lichen planopilaris (LPP) which characterized by triad of fibrosing alopecia of the scalp, non-fibrosing alopecia of the axilla and groin, and a follicular spinous papule over the body. LPP is a rare follicular subtype of lichen planus which causes scarring alopecia of scalp, and there are three clinical subtypes of LPP including classic lichen planopilaris, frontal fibrosing alopecia, and GLPLS. Herein, we describe an adult dark-skinned Saudi male with GLPLS who has numerous body follicular papules, complete loss of axillary hair, and partial loss of groin hair in addition to patchy fibrosing alopecia of the scalp. To the best of our knowledge, this is the first reported case of GLPLS in Saudi Arabia.

摘要

格雷厄姆 - 利特尔 - 皮卡迪 - 拉叙厄尔综合征(GLPLS)是扁平苔藓性毛发角化病(LPP)的一种罕见变体,其特征为头皮纤维化性脱发、腋窝和腹股沟非纤维化性脱发以及身体上的毛囊棘状丘疹三联征。LPP是扁平苔藓的一种罕见毛囊亚型,可导致头皮瘢痕性脱发,LPP有三种临床亚型,包括经典扁平苔藓性毛发角化病、额部纤维化性脱发和GLPLS。在此,我们描述了一名患有GLPLS的成年沙特男性,其皮肤黝黑,除头皮有斑片状纤维化性脱发外,身体有大量毛囊丘疹,腋毛完全脱落,腹股沟毛发部分脱落。据我们所知,这是沙特阿拉伯首例报道的GLPLS病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/c981868ffc93/CCR3-9-e04761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/5cbb519b82cc/CCR3-9-e04761-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/7d7d3f368496/CCR3-9-e04761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/94462851983e/CCR3-9-e04761-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/d28664603f5f/CCR3-9-e04761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/c981868ffc93/CCR3-9-e04761-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/5cbb519b82cc/CCR3-9-e04761-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/7d7d3f368496/CCR3-9-e04761-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/94462851983e/CCR3-9-e04761-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/d28664603f5f/CCR3-9-e04761-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5360/8418680/c981868ffc93/CCR3-9-e04761-g001.jpg

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本文引用的文献

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Dermatol Ther. 2018 Nov;31(6):e12656. doi: 10.1111/dth.12656. Epub 2018 Sep 27.
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Novel Treatment Using Low-Dose Naltrexone for Lichen Planopilaris.低剂量纳曲酮治疗扁平苔藓性毛发角化病的新疗法。
J Drugs Dermatol. 2017 Nov 1;16(11):1140-1142.
头皮、腋窝及身体出现多灶性脱发。
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Photodistributed Lichenoid Eruption with Alopecia: A Unique Presentation of Graham-Little-Piccardi-Lasseur Syndrome.伴有脱发的光分布性苔藓样疹:Graham-Little-Piccardi-Lasseur综合征的一种独特表现。
Int J Trichology. 2023 Jul-Aug;15(4):154-156. doi: 10.4103/ijt.ijt_47_22. Epub 2024 Apr 5.
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Familial Graham-Little-Picardi-Lassueur syndrome across 3 generations.三代家族性格雷厄姆-利特尔-皮卡迪-拉叙厄尔综合征
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