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一项专门为处于疾病早期阶段的精神分裂症/分裂情感障碍患者设计的新型计算机化认知和社会认知训练:一项试点研究。

A new computerized cognitive and social cognition training specifically designed for patients with schizophrenia/schizoaffective disorder in early stages of illness: A pilot study.

机构信息

Research Department. Foundation Parc Taulí. Universitary Institute, Universitat Autònoma de Barcelona. Parc Taulí Sabadell, Universitary Hospital, 08208, Sabadell, Barcelona, Spain; Department of Clinical and Health Psychology, Psychopathology and Neuropsychology Research Unit. Universitat Autònoma de Barcelona, International Excellence Campus, 08193 Bellaterra, Barcelona, Spain.

Research Department. Foundation Parc Taulí. Universitary Institute, Universitat Autònoma de Barcelona. Parc Taulí Sabadell, Universitary Hospital, 08208, Sabadell, Barcelona, Spain; Department of Clinical and Health Psychology, Psychopathology and Neuropsychology Research Unit. Universitat Autònoma de Barcelona, International Excellence Campus, 08193 Bellaterra, Barcelona, Spain.

出版信息

Psychiatry Res. 2015 Aug 30;228(3):501-9. doi: 10.1016/j.psychres.2015.06.007. Epub 2015 Jun 18.

Abstract

People with schizophrenia/schizoaffective disorders at early stages of the illness present cognitive and social cognition deficits that have a great impact in functional outcomes. Cognitive Remediation Therapy (CRT) has demonstrated consistent effect in cognitive performance, symptoms and psychosocial functioning. However, any CRT intervention or social cognition training have been specifically designed for patients in the early stages of psychosis. The aim of this pilot study is to assess the efficacy of a new computerized cognitive and social cognition program for patients with schizophrenia/schizoaffective disorder with recent diagnosis. A comprehensive assessment of clinical, social and non-social cognitive and functional measures was carried out in 53 randomized participants before and after the 4-months treatment. Significant results were observed in Spatial Span Forwards, Immediate Logical Memory and Pictures of Facial Affect (POFA) total score. None of these results were explained by medication, premorbid social functioning or psychopathological symptoms. No impact of the intervention was observed in other cognitive and social cognition outcome neither in clinical and functional outcomes. This new computerized intervention may result effective ameliorating visual attention, logical memory and emotional processing in patients in the early stages of schizophrenia/schizoaffective disorder.

摘要

处于疾病早期阶段的精神分裂症/分裂情感障碍患者存在认知和社会认知缺陷,这对功能结果有很大影响。认知矫正治疗(CRT)已证明在认知表现、症状和心理社会功能方面具有一致的效果。然而,任何 CRT 干预或社会认知训练都是专门为精神病早期阶段的患者设计的。本试点研究旨在评估一种新的计算机化认知和社会认知计划对近期诊断为精神分裂症/分裂情感障碍患者的疗效。在 4 个月的治疗前后,对 53 名随机参与者进行了临床、社会和非社会认知及功能的综合评估。在空间跨度向前、即时逻辑记忆和面部表情图片(POFA)总分方面观察到了显著的结果。这些结果都不能用药物、发病前的社会功能或精神病理症状来解释。在其他认知和社会认知结果以及临床和功能结果中,都没有观察到干预的影响。这种新的计算机化干预可能会有效改善精神分裂症/分裂情感障碍早期患者的视觉注意力、逻辑记忆和情绪处理。

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