绒毛黄檀根中的三种新紫檀烷类化合物——绒毛紫檀素A-C及其细胞毒性
Velucarpins A-C, three new pterocarpans and their cytotoxicity from the roots of Dalbergia velutina.
作者信息
Kaennakam Sutin, Siripong Pongpun, Tip-pyang Santi
机构信息
Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.
Natural Products Research Section, Research Division, National Cancer Institute, Bangkok 10400, Thailand.
出版信息
Fitoterapia. 2015 Sep;105:165-8. doi: 10.1016/j.fitote.2015.07.004. Epub 2015 Jul 9.
Three new pterocarpans, named velucarpins A-C (1-3), along with three known pterocarpans (4-6) were isolated from the roots of Dalbergia velutina. Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against KB and HeLa cell lines. Compounds 3 and 5 showed good cytotoxicity against KB and HeLa cells with IC50 values of 8.22, 8.09 μM and 5.99, 8.69 μM, respectively.
从绒毛黄檀根部分离得到三个新的紫檀烷类化合物，命名为绒毛紫檀素A - C（1 - 3），以及三个已知的紫檀烷类化合物（4 - 6）。通过光谱分析确定了它们的结构。对所有分离得到的化合物进行了针对KB和HeLa细胞系的细胞毒性评估。化合物3和5对KB和HeLa细胞显示出良好的细胞毒性，IC50值分别为8.22、8.09 μM和5.99、8.69 μM。
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