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血清素在呼吸系统功能调节中的作用。

Role of serotonin in the regulation of respiratory system function.

作者信息

Bazarevitch G, Sadekov M, Tereschenko V, Devjataev A, Markarova L

出版信息

Acta Physiol Pol. 1978 Mar-Apr;29(2):131-8.

PMID:26165
Abstract

Role of serotonin in the regulation of respiratory system function. Acta Physiol. Pol., 1978, 29 (2): 131--138. This study examined respiratory centre reflector excitability, the electrical activity of respiratory muscles, outer breathing, pH and arterial blood gas composition under conditions of experimentally induced serotonin excess or deficiency in 48 dogs. It was found that excess of serotonin in the animals leads a strenghthening of respiratory action in terms of increased respiratory centre bioelectrical excitability, muscular electrical activity and outer respiratory indices, such as frequence, volume and lung ventilation per min. In addition the pH of blood shifted to alkalic and oxygen tension of the blood increased while CO2 tension of the blood decreased.

摘要

血清素在呼吸系统功能调节中的作用。《波兰生理学学报》,1978年,29(2):131 - 138。本研究在48只犬身上通过实验诱导血清素过量或缺乏的条件下,检测了呼吸中枢反射兴奋性、呼吸肌电活动、外呼吸、pH值和动脉血气成分。结果发现,动物体内血清素过量会导致呼吸作用增强,表现为呼吸中枢生物电兴奋性增加、肌肉电活动以及外呼吸指标(如频率、每分钟通气量和肺通气量)增加。此外,血液pH值向碱性偏移,血氧张力升高,而血二氧化碳张力降低。

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