Cakebread Julie A, Humphrey Rex, Hodgkinson Alison J
AgResearch, Ruakura Research Centre, Hamilton, New Zealand.
J Agric Food Chem. 2015 Aug 26;63(33):7311-6. doi: 10.1021/acs.jafc.5b01836. Epub 2015 Aug 12.
Immunoglobulin A (IgA) is an anti-inflammatory antibody that plays a critical role in mucosal immunity. It is found in large quantities in human milk, but there are lower amounts in bovine milk. In humans, IgA plays a significant role in providing protection from environmental pathogens at mucosal surfaces and is a key component for the establishment and maintenance of intestinal homeostasis via innate and adaptive immune mechanisms. To date, many of the dairy-based functional foods are derived from bovine colostrum, targeting the benefits of IgG. IgA has a higher pathogenic binding capacity and greater stability against proteolytic degradation when ingested compared with IgG. This provides IgA-based products greater potential in the functional food market that has yet to be realized.
