Turkkan J S, Hienz R D
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Pharmacol Biochem Behav. 1989 Aug;33(4):923-6. doi: 10.1016/0091-3057(89)90495-4.
The effects of single oral doses of the calcium channel blocker nifedipine were assessed on performance of a simultaneous color match-to-sample task in three normotensive baboons. Both accuracy of color matching, and speed and latency of response were measured 30 min after administration of 0.10, 0.34, 0.57, and 1.7 mg/kg and vehicle, with each dose tested on three occasions in randomized order. Systolic and diastolic blood pressures also were measured after testing sessions. Maximal decreases in systolic blood pressures (mean of three subjects = -4.56 mmHg) were obtained after ingestion of the 0.57 mg/kg dose. Nifedipine produced dose-related changes in choice reaction times with a trend toward increased reaction times of approximately 5% obtained at 0.34 and 1.7 mg/kg. A reversal of effect was noted at 0.57 mg/kg such that smaller changes in reaction times were obtained, suggesting a lack of correlation between blood pressure and behavioral performance changes. These results indicate that nifedipine administered in single doses to patients with hypertensive crisis is unlikely to produce large impairments in these aspects of sensory and motor functioning.
在三只血压正常的狒狒身上，评估了单次口服钙通道阻滞剂硝苯地平对同时进行的颜色匹配样本任务表现的影响。在给予0.10、0.34、0.57和1.7mg/kg剂量及赋形剂30分钟后，测量颜色匹配的准确性、反应速度和潜伏期，每个剂量按随机顺序测试三次。测试结束后还测量了收缩压和舒张压。摄入0.57mg/kg剂量后，收缩压出现最大降幅（三名受试者的平均值=-4.56mmHg）。硝苯地平使选择反应时间产生剂量相关变化，在0.34和1.7mg/kg时反应时间有增加约5%的趋势。在0.57mg/kg时观察到效应反转，即反应时间变化较小，这表明血压与行为表现变化之间缺乏相关性。这些结果表明，给高血压危象患者单次服用硝苯地平不太可能在感觉和运动功能的这些方面产生重大损害。
