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从伏石蕨(Phlegmariurus phlegmaria (L.) Holub.)中分离得到的两种新石松生物碱。

Two new Lycopodium alkaloids from Phlegmariurus phlegmaria (L.) Holub.

作者信息

Wang Zhichong, Wu Jichun, Zhao Ningdong, Yang Yiyu, Chen Yegao

机构信息

a Department of Medicinal Chemistry, School of Chemistry and Chemical Engineering, Yunnan Normal University , Chenggong New District, Kunming 650500 , China.

b Department of Natural Medicinal Chemistry, College of Pharmacy, Yanbian University , Yanji 133002 , China.

出版信息

Nat Prod Res. 2016;30(2):241-5. doi: 10.1080/14786419.2015.1046131. Epub 2015 Jul 13.

Abstract

Two new Lycopodium alkaloids, 4β-hydroxynankakurine B (1) and Δ(13,N),N(α)-methylphlegmarine-N(β)-oxide (2), together with three known analogues, lycoposerramine E (3), nankakurine B (4) and lobscurinol (5), were isolated from Phlegmariurus phlegmaria. Their structures were established by mass spectrometry and 1D and 2D NMR techniques.

摘要

从扁枝石松中分离出两种新的石松生物碱,4β-羟基南卡库林B(1)和Δ(13,N),N(α)-甲基弗勒马里胺-N(β)-氧化物(2),以及三种已知类似物,石松色胺E(3)、南卡库林B(4)和洛布库林醇(5)。通过质谱分析以及一维和二维核磁共振技术确定了它们的结构。

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