Movahed Zahra, Kohan Leila, Fallahi Sara, Tabiee Omid
Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.
Department of Biology, Islamic Azad University, Arsanjan Branch, Arsanjan, Iran.
Taiwan J Obstet Gynecol. 2015 Jun;54(3):280-3. doi: 10.1016/j.tjog.2014.05.007.
The purpose of this study was to assess the association between the rs17173608 chemerin polymorphism and polycystic ovary syndrome risk (PCOS).
This case-control study was performed on 150 patients with PCOS and 150 normal women as the control group. Tetra-amplification refractory mutation system-polymerase chain reaction was used to detect the polymorphism.
Our finding showed a positive association between the chemerin gene rs17173608 polymorphism and risk of PCOS. In the dominant effect of the G allele (comparison between TG+GG and TT), TG+GG genotypes were associated with the risk of PCOS (odds ratio = 2; 95% confidence interval = 1.3-3.2, p = 0.003). The G allele is thus dominant and increases the risk of PCOS as compared to the T allele (odds ratio = 1.7, 95% confidence interval = 1.1-2.5, p = 0.009). Nonetheless, there was no significant association between chemerin rs17173608 gene polymorphism and PCOS after adjusting genotypes for body mass index and age.
These results suggested that there was a significant association between chemerin rs17173608 polymorphism and the PCOS; but this relationship was affected by obesity status.
本研究旨在评估趋化素基因rs17173608多态性与多囊卵巢综合征（PCOS）风险之间的关联。
本病例对照研究选取了150例PCOS患者和150例正常女性作为对照组。采用四重扩增阻滞突变系统-聚合酶链反应检测该多态性。
我们的研究结果显示趋化素基因rs17173608多态性与PCOS风险之间存在正相关。在G等位基因的显性效应中（TG + GG与TT比较），TG + GG基因型与PCOS风险相关（比值比 = 2；95%置信区间 = 1.3 - 3.2，p = 0.003）。因此，与T等位基因相比，G等位基因具有显性作用并增加了PCOS风险（比值比 = 1.7，95%置信区间 = 1.1 - 2.5，p = 0.009）。然而，在对体重指数和年龄的基因型进行校正后，趋化素rs17173608基因多态性与PCOS之间无显著关联。
这些结果表明趋化素rs17173608多态性与PCOS之间存在显著关联；但这种关系受肥胖状态的影响。
