Perumalsamy Sangeetha, Wan Ahmad Wan Azman, Zaman Huri Hasniza
Department of Clinical Pharmacy & Pharmacy Practice, Faculty of Pharmacy, University of Malaya, Kuala Lumpur 50603, Malaysia.
Cardiology Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
Healthcare (Basel). 2021 May 23;9(6):623. doi: 10.3390/healthcare9060623.
(1) Background: Chemerin, or the () gene, is found to be associated with an increased incidence of insulin resistance, endothelial dysfunction, type 2 diabetes (T2D), and coronary artery disease (CAD). This study investigates associations of with insulin resistance and the severity of CAD in non-obese T2D patients in relation to the clinical and genetic factors. (2) Methods: A total of 300 patients with T2D and CAD were recruited in this study. The associations of insulin resistance and the severity of CAD with and clinical factors were assessed. The genotyping procedures were performed using the TaqMan method. The significant associations ( ≤ 0.05) from preliminary tests were employed to carry out the secondary analysis. (3) Results: (TT, TG, and GG polymorphisms in the preliminary analysis; TG and GG polymorphisms in a secondary analysis) was associated with insulin resistance and the severity of CAD in both the preliminary and secondary analysis (all -values were < 0.05). Additionally, in the secondary analysis, FPG and ACEI were also associated with insulin resistance and the severity of CAD (all -values were < 0.05). (4) Conclusion: From the preliminary findings, is a significant predictor of insulin resistance and the severity of CAD.
(1) 背景：发现chemerin或（）基因与胰岛素抵抗、内皮功能障碍、2型糖尿病（T2D）和冠状动脉疾病（CAD）发病率增加相关。本研究调查了在非肥胖T2D患者中，与胰岛素抵抗及CAD严重程度相关的临床和遗传因素。(2) 方法：本研究共招募了300例患有T2D和CAD的患者。评估了胰岛素抵抗及CAD严重程度与及临床因素之间的关联。使用TaqMan方法进行基因分型操作。采用初步测试中具有显著关联（≤0.05）的数据进行二次分析。(3) 结果：（初步分析中的TT、TG和GG多态性；二次分析中的TG和GG多态性）在初步分析和二次分析中均与胰岛素抵抗及CAD严重程度相关（所有P值均<0.05）。此外，在二次分析中，空腹血糖（FPG）和血管紧张素转换酶抑制剂（ACEI）也与胰岛素抵抗及CAD严重程度相关（所有P值均<0.05）。(4) 结论：根据初步研究结果，是胰岛素抵抗及CAD严重程度的重要预测指标。
