The Division of Endocrinology and Metabolism, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
School of Medicine, Tzu Chi University, Hualien, Taiwan.
Mediators Inflamm. 2018 Mar 12;2018:4670521. doi: 10.1155/2018/4670521. eCollection 2018.
Chemerin, an adipokine and inflammatory mediator, is associated with metabolic, inflammation- and immune-mediated diseases. The genetic, clinical, and biomarker correlates of circulating chemerin levels have not been completely elucidated. We analyzed the determinants and correlates of retinoic acid receptor responder 2 (; encoding chemerin) gene variants and chemerin levels in the Taiwanese population. In total, 612 individuals were recruited. Clinical and metabolic phenotypes, 13 inflammatory markers, 5 adipokines, and 6 single-nucleotide polymorphisms (SNPs) covering the region were analyzed. High chemerin levels and chemerin level tertiles were positively associated with multiple metabolic phenotypes and circulating inflammatory marker and adipokine levels and negatively associated with high-density lipoprotein cholesterol and adiponectin levels and estimated glomerular filtration rates (eGFRs). Genotype and haplotype analyses showed that SNPs were significantly associated with chemerin, fibrinogen, interleukin 6, and lipocalin 2 levels. Stepwise logistic regression analysis showed that C-reactive protein level, leptin level, triglyceride level, eGFR, rs3735167 genotypes, sex, and soluble P-selectin level were independently associated with chemerin levels. In conclusion, pleiotropic associations were noted between variants, circulating chemerin levels and multiple metabolic phenotypes and inflammatory marker levels. This study provides further evidence for the potential roles of chemerin in metabolic and inflammation-related diseases.
趋化素是一种脂肪因子和炎症介质，与代谢、炎症和免疫介导的疾病有关。循环趋化素水平的遗传、临床和生物标志物相关性尚未完全阐明。我们分析了台湾人群中视黄酸受体应答基因 2（编码趋化素）基因变异和趋化素水平的决定因素和相关性。共招募了 612 人。分析了临床和代谢表型、13 种炎症标志物、5 种脂肪因子和 6 个覆盖 区域的单核苷酸多态性（SNP）。高趋化素水平和趋化素水平三分位与多种代谢表型以及循环炎症标志物和脂肪因子水平呈正相关，与高密度脂蛋白胆固醇和脂联素水平以及估算肾小球滤过率（eGFR）呈负相关。基因型和单倍型分析表明，3 个 SNP 与趋化素、纤维蛋白原、白细胞介素 6 和脂钙蛋白 2 水平显著相关。逐步逻辑回归分析表明，C 反应蛋白水平、瘦素水平、甘油三酯水平、eGFR、rs3735167 基因型、性别和可溶性 P 选择素水平与趋化素水平独立相关。总之， 变体、循环趋化素水平与多种代谢表型和炎症标志物水平之间存在多种关联性。本研究为趋化素在代谢和炎症相关疾病中的潜在作用提供了进一步的证据。
