Aune Thomas M, Spurlock Charles F
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37212, United States.
Virus Res. 2016 Jan 2;212:146-60. doi: 10.1016/j.virusres.2015.07.003. Epub 2015 Jul 9.
Long noncoding RNAs (lncRNAs) represent a newly discovered class of regulatory molecules that impact a variety of biological processes in cells and organ systems. In humans, it is estimated that there may be more than twice as many lncRNA genes than protein-coding genes. However, only a handful of lncRNAs have been analyzed in detail. In this review, we describe expression and functions of lncRNAs that have been demonstrated to impact innate and adaptive immunity. These emerging paradigms illustrate remarkably diverse mechanisms that lncRNAs utilize to impact the transcriptional programs of immune cells required to fight against pathogens and maintain normal health and homeostasis.
长链非编码RNA（lncRNAs）是一类新发现的调节分子，可影响细胞和器官系统中的多种生物学过程。据估计，在人类中，lncRNA基因的数量可能是蛋白质编码基因的两倍多。然而，只有少数lncRNAs得到了详细分析。在这篇综述中，我们描述了已被证明影响先天性和适应性免疫的lncRNAs的表达和功能。这些新出现的模式阐明了lncRNAs用于影响免疫细胞转录程序的显著多样的机制，这些转录程序是对抗病原体以及维持正常健康和体内平衡所必需的。
