Vierbuchen Tim, Fitzgerald Katherine A
Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States.
Program in Innate Immunity, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, United States.
Semin Cell Dev Biol. 2021 Mar;111:126-134. doi: 10.1016/j.semcdb.2020.06.009. Epub 2020 Jun 21.
Tight regulation of the immune response is fundamental for efficient pathogen clearance and to prevent excessive inflammation. Long non-coding RNAs (lncRNAs) have emerged as potent regulators of the innate and adaptive immune responses to viral pathogens. Host-derived lncRNAs control the differentiation and polarization of immune cell populations and the production of cytokines, interferons and antiviral factors. This review provides an updated overview of lncRNAs that modulate viral replication or pathogenesis. Beyond that, viruses have developed lncRNA-based strategies to mask themselves from immune detection and evade antiviral immunity. A deeper understanding of lncRNA biology in the context of host-pathogen interactions may unveil new treatment strategies in the near future.
对免疫反应进行严格调控对于有效清除病原体和预防过度炎症至关重要。长链非编码RNA（lncRNAs）已成为对病毒病原体先天性和适应性免疫反应的有力调节因子。宿主来源的lncRNAs控制免疫细胞群体的分化和极化以及细胞因子、干扰素和抗病毒因子的产生。本综述提供了对调节病毒复制或发病机制的lncRNAs的最新概述。除此之外，病毒还开发了基于lncRNA的策略来隐藏自身以逃避免疫检测和抗病毒免疫。在宿主-病原体相互作用的背景下对lncRNA生物学有更深入的了解，可能在不久的将来揭示新的治疗策略。
