Zhang Hua Wei, Meng Xing Yu, Li An Feng, Yang Yu Ying, Qiu Hua Ji
State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China.
College of Animal Sciences, Yangtze University, Jingzhou 434023, China.
Yi Chuan. 2018 Jul 20;40(7):525-533. doi: 10.16288/j.yczz.18-065.
Long non-coding RNAs (lncRNAs) are designated as the transcripts longer than 200 nucleotides without protein-coding capacity. As a category of important gene regulatory factors, lncRNAs regulate the expression of target genes at epigenetic, transcription and post-transcriptional levels by various mechanisms, such as chromatin remodeling, DNA modification, transcription inhibition and RNA-RNA interactions, etc. In recent years, studies have shown that many lncRNAs can be induced by viruses or interferon (IFN) and to regulate the expression of related antiviral genes in IFN-mediated antiviral innate immune responses. In this review, we focus on the regulation of lncRNAs in IFN-mediated antiviral innate immune responses, especially in the transcription of IFN-stimulated genes (ISGs). In addition, we summarize the regulatory network of lncRNAs, IFN and ISGs. This review will provide a valuable reference for the researchers working in this field.
长链非编码RNA（lncRNAs）是指长度超过200个核苷酸且无蛋白质编码能力的转录本。作为一类重要的基因调控因子，lncRNAs通过多种机制，如染色质重塑、DNA修饰、转录抑制和RNA-RNA相互作用等，在表观遗传、转录和转录后水平上调控靶基因的表达。近年来，研究表明许多lncRNAs可被病毒或干扰素（IFN）诱导，并在IFN介导的抗病毒天然免疫反应中调控相关抗病毒基因的表达。在本综述中，我们重点关注lncRNAs在IFN介导的抗病毒天然免疫反应中的调控作用，尤其是在干扰素刺激基因（ISGs）转录过程中的作用。此外，我们总结了lncRNAs、IFN和ISGs的调控网络。本综述将为该领域的研究人员提供有价值的参考。
