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Transcription factor IRF8 controls Th1-like regulatory T-cell function.
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T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2.
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Generation of human Th1-like regulatory CD4+ T cells by an intrinsic IFN-γ- and T-bet-dependent pathway.
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The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation.
Nat Immunol. 2009 Jun;10(6):595-602. doi: 10.1038/ni.1731. Epub 2009 May 3.
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T-Bet Enhances Regulatory T Cell Fitness and Directs Control of Th1 Responses in Crescentic GN.
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CXCR3+ T regulatory cells selectively accumulate in human ovarian carcinomas to limit type I immunity.
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10
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity. 2012 Sep 21;37(3):511-23. doi: 10.1016/j.immuni.2012.06.014. Epub 2012 Sep 13.

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Treg plasticity and human diseases.
Inflamm Res. 2023 Dec;72(12):2181-2197. doi: 10.1007/s00011-023-01808-x. Epub 2023 Oct 25.
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Chronic CD27-CD70 costimulation promotes type 1-specific polarization of effector Tregs.
Front Immunol. 2023 Mar 13;14:1023064. doi: 10.3389/fimmu.2023.1023064. eCollection 2023.
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reconstruction and identification of transcriptional gene regulatory network modules differentiating single-cell clusters.
NAR Genom Bioinform. 2023 Mar 3;5(1):lqad018. doi: 10.1093/nargab/lqad018. eCollection 2023 Mar.
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Reduced Renal CSE/CBS/H2S Contributes to the Progress of Lupus Nephritis.
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Biosensors for inflammation as a strategy to engineer regulatory T cells for cell therapy.
Proc Natl Acad Sci U S A. 2022 Oct 4;119(40):e2208436119. doi: 10.1073/pnas.2208436119. Epub 2022 Sep 26.

本文引用的文献

1
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology.
Immunity. 2012 Sep 21;37(3):511-23. doi: 10.1016/j.immuni.2012.06.014. Epub 2012 Sep 13.
2
A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells.
Nat Immunol. 2012 Oct;13(10):972-80. doi: 10.1038/ni.2420. Epub 2012 Sep 9.
3
CXCR3+ T regulatory cells selectively accumulate in human ovarian carcinomas to limit type I immunity.
Cancer Res. 2012 Sep 1;72(17):4351-60. doi: 10.1158/0008-5472.CAN-12-0579. Epub 2012 Jul 12.
4
Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells.
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12123-8. doi: 10.1073/pnas.1201453109. Epub 2012 Jul 10.
5
Regulatory T cells: mechanisms of differentiation and function.
Annu Rev Immunol. 2012;30:531-64. doi: 10.1146/annurev.immunol.25.022106.141623. Epub 2012 Jan 6.
6
Distinct regulatory CD4+T cell subsets; differences between naïve and antigen specific T regulatory cells.
Curr Opin Immunol. 2011 Oct;23(5):641-7. doi: 10.1016/j.coi.2011.07.012. Epub 2011 Aug 11.
7
Foxp3+ follicular regulatory T cells control the germinal center response.
Nat Med. 2011 Jul 24;17(8):975-82. doi: 10.1038/nm.2425.
10
Phenotypical and functional specialization of FOXP3+ regulatory T cells.
Nat Rev Immunol. 2011 Feb;11(2):119-30. doi: 10.1038/nri2916.

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