Kulkarni Yogesh A, Agarwal Sneha, Garud Mayuresh S
Department of Pharmacology, Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, Shri Vile Parle Kelavani Mandal's Narsee Monjee Institute of Management Studies, Mumbai, Maharashtra, India.
J Ayurveda Integr Med. 2015 Apr-Jun;6(2):82-8. doi: 10.4103/0975-9476.146540.
Jyotishmati, scientifically known as Celastrus paniculatus Wild (Celastraceae) is one of the most important medicinal plants in Ayurveda. The plant has shown significant pharmacological activities like anti-arthritic, wound healing, hypolipidemic, and antioxidant.
To study possible effects of alcoholic extract of Celastrus paniculatus seeds (AlcE) in experimentally induced pain and inflammation in mice.
The antinociceptive activity was evaluated in Swiss albino mice by tail immersion, hot plate, and acetic-acid-induced writhing tests at doses of 250, 500, and 1,000 mg/kg. Anti-inflammatory activity was evaluated in model of carrageenan-induced acute plantar inflammation in Wistar rats.
In tail immersion test, AlcE showed significant (P < 0.05) increase in tail withdrawal response at dose of 250 mg/kg with maximum possible effect of 15.71%. The maximum possible effect of 23.32% and 30.16% (P < 0.001) was seen at dose of 500 and 1000 mg/kg at 3 hours after administration of extract, respectively. In hot plate test, increase in paw licking time was reported at dose of 500 and 1000 mg/kg. AlcE (1,000 mg/kg) showed maximum response (6.23 ± 0.46) when compared with control (3.20 ± 0.18) at 90 min. In acetic acid induced writhings, AlcE at dose of 250, 500, and 1,000 mg/kg body weight showed 32.35%, 49.01%, and 58.82% inhibition in writhings, respectively. AlcE treated animals (500 and 1,000 mg/kg) showed significant decrease in paw edema at 3 hours and 4 hours, when compared with control animals.
Jyotishmati seed extract possesses significant antinociceptive and anti-inflammatory activity.
乔蒂什马蒂，科学名称为南蛇藤（卫矛科），是阿育吠陀医学中最重要的药用植物之一。该植物已显示出显著的药理活性，如抗关节炎、伤口愈合、降血脂和抗氧化作用。
研究南蛇藤种子醇提取物（AlcE）对实验诱导的小鼠疼痛和炎症的可能影响。
通过尾浸法、热板法和醋酸诱导扭体试验，以250、500和1000mg/kg的剂量在瑞士白化小鼠中评估抗伤害感受活性。在Wistar大鼠角叉菜胶诱导的急性足底炎症模型中评估抗炎活性。
在尾浸试验中，AlcE在250mg/kg剂量时显示出显著（P<0.05）的尾退缩反应增加，最大可能效应为15.71%。在提取物给药后3小时，500和1000mg/kg剂量时分别观察到最大可能效应为23.32%和30.16%（P<0.001）。在热板试验中，500和1000mg/kg剂量时报告舔爪时间增加。与对照组（3.20±0.18）相比，AlcE（1000mg/kg）在90分钟时显示出最大反应（6.23±0.46）。在醋酸诱导的扭体试验中，250、500和1000mg/kg体重剂量的AlcE分别显示出32.35%、49.01%和58.82%的扭体抑制率。与对照动物相比，AlcE处理的动物（500和1000mg/kg）在3小时和4小时时爪水肿显著减轻。
乔蒂什马蒂种子提取物具有显著的抗伤害感受和抗炎活性。
