Kulkarni Yogesh A, Panjabi Ritesh, Patel Vishvas, Tawade Aditi, Gokhale Alok
Department of Pharmacology, SPP-School of Pharmacy and Technology Management, SVKM's NMIMS University, Mumbai, India.
J Ayurveda Integr Med. 2013 Jul;4(3):152-7. doi: 10.4103/0975-9476.118697.
Gmelina arborea Roxb (Verbenaceae), also known as "Gambhari", is an important medicinal plant in the Ayurveda. There are no meticulous scientific reports on effect of the plant on inflammation and pain.
To study the anti-inflammatory and anti-nociceptive properties of aqueous extracts (AE) and methanol extracts (ME) of G. arborea.
The AE and ME of stembark of G. arborea was prepared by cold maceration and Soxhlet extraction technique respectively. Anti-inflammatory activity was determined in Wistar albino rats in a model of acute plantar inflammation induced by carrageenan. The anti-nociceptive activity was evaluated by using hot plate test and writhing test in Swiss albino mice. Significant differences between the experimental groups were assessed by analysis of variance.
AE and ME at dose of 500 mg/kg showed maximum inhibition in carrageenan induced inflammation up to 30.15 and 31.21% respectively. In hot plate test, the AE and ME showed the maximum response of 8.8 ± 0.97 (P < 0.01) and 8.2 ± 1.24 (P < 0.01) respectively at dose of 500 mg/kg when compared with control. AE showed maximum inhibition of writhing response (84.3%) as compared to ME (77.9%) in writhing test at a dose of 500 mg/kg.
The findings suggested that G. arborea possess significant anti-inflammatory and anti-nociceptive activities.
乔木九层皮（马鞭草科），也被称为“甘巴里”，是阿育吠陀医学中的一种重要药用植物。关于该植物对炎症和疼痛影响的详细科学报告尚未见报道。
研究乔木九层皮水提取物（AE）和甲醇提取物（ME）的抗炎和抗伤害感受特性。
分别采用冷浸法和索氏提取法制备乔木九层皮茎皮的AE和ME。在角叉菜胶诱导的急性足底炎症模型中，测定Wistar白化大鼠的抗炎活性。通过热板试验和扭体试验评估瑞士白化小鼠的抗伤害感受活性。通过方差分析评估实验组之间的显著差异。
500mg/kg剂量的AE和ME在角叉菜胶诱导的炎症中分别显示出高达30.15%和31.21%的最大抑制率。在热板试验中，与对照组相比，500mg/kg剂量的AE和ME分别显示出最大反应8.8±0.97（P<0.01）和8.2±1.24（P<0.01）。在500mg/kg剂量的扭体试验中，AE显示出比ME（77.9%）更大的扭体反应抑制率（84.3%）。
研究结果表明乔木九层皮具有显著的抗炎和抗伤害感受活性。
