Alfaro David, Rodríguez-Sosa Mariano R, Zapata Agustín G
Department of Cell Biology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain.
J Clin Med. 2020 Jan 22;9(2):310. doi: 10.3390/jcm9020310.
Mesenchymal stromal/stem cells (MSCs) have emerged as important therapeutic agents, owing to their easy isolation and culture, and their remarkable immunomodulatory and anti-inflammatory properties. However, MSCs constitute a heterogeneous cell population which does not express specific cell markers and has important problems for in vivo homing, and factors regulating their survival, proliferation, and differentiation are largely unknown. Accordingly, in the present article, we review the current evidence on the relationships between Eph kinase receptors, their ephrin ligands, and MSCs. These molecules are involved in the adult homeostasis of numerous tissues, and we and other authors have demonstrated their expression in human and murine MSCs derived from both bone marrow and adipose tissue, as well as their involvement in the MSC biology. We extend these studies providing new results on the effects of Eph/ephrins in the differentiation and immunomodulatory properties of MSCs.
间充质基质/干细胞（MSCs）已成为重要的治疗剂，这得益于其易于分离和培养，以及显著的免疫调节和抗炎特性。然而，MSCs构成了一个异质性细胞群体，不表达特异性细胞标志物，在体内归巢方面存在重要问题，而且调节其存活、增殖和分化的因素很大程度上尚不清楚。因此，在本文中，我们综述了目前关于Eph激酶受体、其 Ephrin 配体与MSCs之间关系的证据。这些分子参与多种组织的成体稳态，我们和其他作者已证明它们在源自骨髓和脂肪组织的人及小鼠MSCs中的表达，以及它们在MSCs生物学中的作用。我们扩展了这些研究，提供了关于Eph/Ephrins对MSCs分化和免疫调节特性影响的新结果。
