雌激素受体α、孕激素受体及表皮生长因子受体在甲状腺乳头状癌组织中的表达
Expression of the estrogen receptor α, progesterone receptor and epidermal growth factor receptor in papillary thyroid carcinoma tissues.
作者信息
Chen Dan, Qi Wenjing, Zhang Pengxin, Guan Hongwei, Wang Lifen
机构信息
Department of Pathology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P.R. China.
Department of Pathology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116023, P.R. China.
出版信息
Oncol Lett. 2015 Jul;10(1):317-320. doi: 10.3892/ol.2015.3223. Epub 2015 May 19.
The present study aimed to determine the protein expression, in addition to the clinical value of the expression, of estrogen receptor α (ERα), progesterone receptor (PR) and epidermal growth factor receptor (EGFR) in papillary thyroid carcinoma (PTC). The expression of ERα, PR and EGFR was examined immunohistochemically on paraffin-embedded thyroid tissues obtained from 64 patients with PTC and 14 patients with nodular thyroid goiter (NTG). The expression level of ERα, PR and EGFR was found to be significantly elevated in the PTC tissues compared with the NTG tissues. In addition, the expression of ERα was found to be correlated with the size of PTC tumors. However, there was no significant difference between the expression levels of ERα, PR and EGFR in males and females with PTC. Thus, immunohistochemical evaluation of ERα, PR and EGFR expression in patients with PTC may aid in the prediction of the prognosis of patients with PTC.
本研究旨在确定雌激素受体α（ERα）、孕激素受体（PR）和表皮生长因子受体（EGFR）在甲状腺乳头状癌（PTC）中的蛋白表达及其表达的临床价值。采用免疫组织化学方法检测了64例PTC患者和14例结节性甲状腺肿（NTG）患者石蜡包埋甲状腺组织中ERα、PR和EGFR的表达。结果发现，与NTG组织相比，PTC组织中ERα、PR和EGFR的表达水平显著升高。此外，还发现ERα的表达与PTC肿瘤大小相关。然而，PTC男性和女性患者中ERα、PR和EGFR的表达水平无显著差异。因此，对PTC患者进行ERα、PR和EGFR表达的免疫组织化学评估可能有助于预测PTC患者的预后。
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