School of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Research and Innovation Team of Emotional Diseases and Syndromes of Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Chin J Integr Med. 2023 Jun;29(6):566-576. doi: 10.1007/s11655-022-3724-3. Epub 2022 Aug 31.
Nodular goiter has become increasingly prevalent in recent years. Clinically, there has been a burgeoning interest in nodular goiter due to the risk of progression to thyroid cancer. This review aims to provide a comprehensive summary of the mechanisms underlying the therapeutic effect of Chinese medicine (CM) in nodular goiter. Articles were systematically retrieved from databases, including PubMed, Web of Science and China National Knowledge Infrastructure. New evidence showed that CM exhibited multi-pathway and multi-target characteristics in the treatment of nodular goiter, involving hypothalamus-pituitary-thyroid axis, oxidative stress, blood rheology, cell proliferation, apoptosis, and autophagy, especially inhibition of cell proliferation and promotion of cell apoptosis, involving multiple signal pathways and a variety of cytokines. This review provides a scientific basis for the therapeutic use of CM against nodular goiter. Nonetheless, future studies are warranted to identify more regulatory genes and pathways to provide new approaches for the treatment of nodular goiter.
近年来，结节性甲状腺肿的发病率呈上升趋势。由于结节性甲状腺肿有进展为甲状腺癌的风险，临床上对其的关注度日益增加。本综述旨在全面总结中医药治疗结节性甲状腺肿的作用机制。文章系统地从 PubMed、Web of Science 和中国知网等数据库中检索。新的证据表明，中医药在治疗结节性甲状腺肿方面具有多途径、多靶点的特点，涉及下丘脑-垂体-甲状腺轴、氧化应激、血液流变学、细胞增殖、凋亡和自噬，特别是抑制细胞增殖和促进细胞凋亡，涉及多种信号通路和多种细胞因子。本综述为中医药治疗结节性甲状腺肿提供了科学依据。然而，仍需要进一步的研究来确定更多的调控基因和通路，为结节性甲状腺肿的治疗提供新的方法。
