Tian Jin, Liu Xin Chao, Liu Zhi Long, Lai Daowan, Zhou Ligang
MOA Key Laboratory of Plant Pathology, Department of Plant Pathology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Department of Entomology, College of Agronomy and Biotechnology, China Agricultural University, Beijing, China.
Pest Manag Sci. 2016 May;72(5):961-5. doi: 10.1002/ps.4075. Epub 2015 Jul 31.
In our screening programme for new agrochemicals from endophytic fungi, the ethyl acetate extract of an endophytic Berkleasmium sp. isolated from the medicinal plant Dioscorea zingiberensis was found to possess strong larvicidal activity against the Asian tiger mosquito, Aedes albopictus.
Bioassay-guided fractionation of the fungal extract has led to the isolation of seven spirobisnaphthalenes, including palmarumycins C8, C12, C15 and B6 and diepoxins γ, δ and ζ. Among them, palmarumycins C8 and B6 showed strong larvicidal activity against the fourth-instar larvae of A. albopictus, with LC50 values of 8.83 and 11.51 µg mL(-1) respectively. Interestingly, only spirobisnaphthalenes with a chlorine substituent possessed strong larvicidal activity.
The results indicated that the spirobisnaphthalenes derived from the endophytic fungus Berkleasmium sp. could be promising leads for the development of new larvicides against A. albopictus.
在我们从内生真菌中筛选新型农用化学品的项目中，从药用植物盾叶薯蓣中分离出的一种内生拟茎点霉属真菌的乙酸乙酯提取物，被发现对亚洲虎蚊白纹伊蚊具有很强的杀幼虫活性。
对该真菌提取物进行生物测定导向的分级分离，得到了七种螺二萘类化合物，包括棕榈霉素C8、C12、C15和B6以及双环氧物γ、δ和ζ。其中，棕榈霉素C8和B6对白纹伊蚊四龄幼虫表现出很强的杀幼虫活性，LC50值分别为8.83和11.51 µg mL(-1)。有趣的是，只有带有氯取代基的螺二萘类化合物具有很强的杀幼虫活性。
结果表明，源自内生真菌拟茎点霉属的螺二萘类化合物可能是开发新型白纹伊蚊杀幼虫剂的有前景的先导化合物。
Zotero 插件